Myo18a MGI Mouse Gene Detail - MGI:2667185

Symbol

Myo18a
Name

myosin XVIIIA
Synonyms

MyoPDZ

Feature Type

protein coding gene
IDs

MGI:2667185
NCBI Gene: 360013
Alliance

gene page
Transcription Start Sites

20 TSS

Sequence Map

Chr11:77654072-77756806 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 46.74 cM
Mapping Data

1 experiment

SNPs within 2kb

2369 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2667185	protein coding gene	Chr11:77654066-77756806 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018755	protein coding gene	Chr11:78712335-78820533 (+)
A/J	MGP_AJ_G0018721	protein coding gene	Chr11:75713607-75818757 (+)
AKR/J	MGP_AKRJ_G0018691	protein coding gene	Chr11:78015405-78125257 (+)
BALB/cJ	MGP_BALBcJ_G0018695	protein coding gene	Chr11:76110561-76214187 (+)
C3H/HeJ	MGP_C3HHeJ_G0018508	protein coding gene	Chr11:78050308-78155889 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019146	protein coding gene	Chr11:81181004-81290707 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016781	protein coding gene	Chr11:72689218-72796508 (+)
CAST/EiJ	MGP_CASTEiJ_G0018062	protein coding gene	Chr11:78458390-78575507 (+)
CBA/J	MGP_CBAJ_G0018478	protein coding gene	Chr11:84709882-84829363 (+)
DBA/2J	MGP_DBA2J_G0018587	protein coding gene	Chr11:75300505-75403966 (+)
FVB/NJ	MGP_FVBNJ_G0018577	protein coding gene	Chr11:74880519-74985121 (+)
LP/J	MGP_LPJ_G0018658	protein coding gene	Chr11:79261088-79365984 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018603	protein coding gene	Chr11:85161028-85281230 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019186	protein coding gene	Chr11:78245729-78354540 (+)
PWK/PhJ	MGP_PWKPhJ_G0017833	protein coding gene	Chr11:76068014-76173886 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017624	protein coding gene	Chr11:77843504-77957752 (+)
WSB/EiJ	MGP_WSBEiJ_G0018115	protein coding gene	Chr11:78059646-78164584 (+)

Human Ortholog

MYO18A, myosin XVIIIA

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MYO18A, myosin XVIIIA
Synonyms

MAJN, MYSPDZ, SP-R210, SPR210, TIAF1
Links

HGNC:31104

NCBI Gene ID: 399687

neXtProt AC: NX_O95411, NX_Q92614

UniProt: O95411, Q92614
Chr Location

17q11.2; chr17:29071122-29180398 (-) GRCh38

MGI Vertebrate Homology

Myo18a stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MYO18A
Gene Tree

Myo18a

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Phenotype Summary

12 phenotypes from 3 alleles in 4 genetic backgrounds
2 phenotypes from multigenic genotypes
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

57
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

47
Targeted

7
Genomic Mutations

2 involving Myo18a
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

124 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a null allele exhibit embryonic lethality before E13.5, with abnormal myofibrils in cardiac myocytes.

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All GO Annotations

39
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

860
Tissues

32
cDNA Data

9
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase myo18a

ZFIN myo18aa, myo18ab

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All Sequences

162
RefSeq

70
UniProt

13
CCDS

CCDS25085.1, CCDS70252.1, CCDS70253.1, CCDS78997.1, CCDS83849.1

Ensembl

ENSMUSG00000000631 (Evidence)
NCBI Gene

360013

			Length	Strain/Species	Flank
genomic	ENSMUSG00000000631	Ensembl Gene Model \| MGI Sequence Detail	102735	C57BL/6J	± kb
transcript	ENSMUST00000168348	Ensembl \| MGI Sequence Detail	6582	Not Applicable
polypeptide	ENSMUSP00000130696	Ensembl \| MGI Sequence Detail	2083	Not Applicable

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UniProt

13 Sequences
Protein Ontology

PR:000010852 myosin-XVIIIa

(term hierarchy)
InterPro Domains

IPR036064 Class XVIII myosin, motor domain

IPR000048 IQ motif, EF-hand binding site

IPR036961 Kinesin motor domain superfamily

IPR001609 Myosin head, motor domain

IPR004009 Myosin, N-terminal, SH3-like

IPR002928 Myosin tail

IPR051067 Na+/H+ exchange regulatory cofactor

IPR001478 PDZ domain

IPR036034 PDZ superfamily

IPR027417 P-loop containing nucleoside triphosphate hydrolase
GlyGen

Q9JMH9 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 10

cDNA 9

Primer pair 1

Microarray probesets 3

Summaries

All 52

Developmental Gene Expression 5

Gene Ontology 11

Phenotypes 23
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Myo18a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr103179	Chr11:77654095-77654165 (+)	58 bp
Tssr103180	Chr11:77656414-77656469 (+)	2,370 bp
Tssr103181	Chr11:77656478-77656491 (+)	2,413 bp
Tssr103182	Chr11:77661707-77661711 (+)	7,637 bp
Tssr103183	Chr11:77691980-77691992 (+)	37,914 bp
Tssr103184	Chr11:77692117-77692147 (+)	38,060 bp
Tssr103185	Chr11:77692151-77692181 (+)	38,094 bp
Tssr103186	Chr11:77693196-77693223 (+)	39,138 bp
Tssr103187	Chr11:77693232-77693248 (+)	39,168 bp
Tssr103188	Chr11:77693250-77693261 (+)	39,184 bp
Tssr103189	Chr11:77702040-77702053 (+)	47,975 bp
Tssr103190	Chr11:77728831-77728835 (+)	74,761 bp
Tssr103191	Chr11:77728873-77728901 (+)	74,815 bp
Tssr103192	Chr11:77728908-77728932 (+)	74,848 bp
Tssr103193	Chr11:77728945-77728952 (+)	74,877 bp
Tssr103194	Chr11:77728953-77728974 (+)	74,892 bp
Tssr103195	Chr11:77731080-77731090 (+)	77,013 bp
Tssr103196	Chr11:77731094-77731124 (+)	77,037 bp
Tssr103197	Chr11:77741548-77741559 (+)	87,482 bp
Tssr103198	Chr11:77744432-77744480 (+)	90,384 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24