About   Help   FAQ
Sdr16c5 Gene Detail
Summary
  • Symbol
    Sdr16c5
  • Name
    short chain dehydrogenase/reductase family 16C, member 5
  • Synonyms
    Rdhe2, Scdr9
  • Feature Type
    protein coding gene
  • IDs
    MGI:2668443
    NCBI Gene: 242285
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:3995942-4019663 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 2.23 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    627 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2668443
 protein coding gene Chr4:3995936-4019663 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028028
 protein coding gene Chr4:498098-512279 (-)
A/J MGP_AJ_G0027986
 protein coding gene Chr4:578125-592340 (-)
AKR/J MGP_AKRJ_G0027952
 protein coding gene Chr4:511215-525412 (-)
BALB/cJ MGP_BALBcJ_G0027998
 protein coding gene Chr4:535922-550125 (-)
C3H/HeJ MGP_C3HHeJ_G0027728
 protein coding gene Chr4:681930-696109 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028441
 protein coding gene Chr4:669286-698455 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025785
 protein coding gene Chr4:509965-524313 (-)
CAST/EiJ MGP_CASTEiJ_G0027181
 protein coding gene Chr4:581843-598611 (-)
CBA/J MGP_CBAJ_G0027703
 protein coding gene Chr4:549358-563525 (-)
DBA/2J MGP_DBA2J_G0027843
 protein coding gene Chr4:532796-547001 (-)
FVB/NJ MGP_FVBNJ_G0027810
 protein coding gene Chr4:465902-480072 (-)
LP/J MGP_LPJ_G0027954
 protein coding gene Chr4:549184-563357 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027843
 protein coding gene Chr4:723423-737620 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028500
 protein coding gene Chr4:505058-520509 (-)
PWK/PhJ MGP_PWKPhJ_G0026903
 protein coding gene Chr4:611473-629415 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026733
 protein coding gene Chr4:544529-558442 (-)
WSB/EiJ MGP_WSBEiJ_G0027261
 protein coding gene Chr4:656736-670929 (-)



Homology
more
  • Human Ortholog
    SDR16C5, short chain dehydrogenase/reductase family 16C member 5
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SDR16C5, short chain dehydrogenase/reductase family 16C member 5
  • Synonyms
    EPHD-2, RDH#2, RDH-E2, RDHE2, retSDR2
  • Links
    NCBI Gene ID: 195814
    neXtProt AC: NX_Q8N3Y7
    UniProt: Q8N3Y7

  • Chr Location
    8q12.1; chr8:56300005-56320776 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from multigenic genotypes
    5 phenotype references
Mice homozygous for a deletion of Sdr16c5 and Sdr16c6 exhibit accelerated hair growth enlarged meibomian glands.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    94
  • cDNA Data
    7
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 242285 NCBI Gene Model | MGI Sequence Detail 23722 C57BL/6J ±  kb
transcript NM_181989 RefSeq | MGI Sequence Detail 1379 Not Specified  
polypeptide Q7TQA3 UniProt | EBI | MGI Sequence Detail 309 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 7
    cDNA 7

    Microarray probesets 3
References
more
  • Summaries
    All 31
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 5
  • Earliest
    J:122989 Visel A, et al., GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
  • Latest
    J:340060 Butovich IA, et al., Sdr16c5 and Sdr16c6 control a dormant pathway at a bifurcation point between meibogenesis and sebogenesis. J Biol Chem. 2023 Apr 17;299(6):104725
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory