H3c1 MGI Mouse Gene Detail - MGI:2668828

Symbol

H3c1
Name

H3 clustered histone 1
Synonyms

Hist1h3a

Feature Type

protein coding gene
IDs

MGI:2668828
NCBI Gene: 360198
Member of

Hist1 cluster
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr13:23945868-23946369 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 9.91 cM, cytoband A2-A3
Mapping Data

1 experiment

SNPs within 2kb

148 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2668828	protein coding gene	Chr13:23945836-23946369 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020366	protein coding gene	Chr13:21205757-21207436 (-)
A/J	MGP_AJ_G0020315	protein coding gene	Chr13:20815006-20816335 (-)
AKR/J	MGP_AKRJ_G0020295	protein coding gene	Chr13:21068654-21069187 (-)
BALB/cJ	MGP_BALBcJ_G0020313	protein coding gene	Chr13:20811477-20812010 (-)
C3H/HeJ	MGP_C3HHeJ_G0020117	protein coding gene	Chr13:21141231-21141764 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020750	protein coding gene	Chr13:21985879-21987200 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018338	protein coding gene	Chr13:19588803-19589330 (-)
CAST/EiJ	MGP_CASTEiJ_G0026774	protein coding gene	Chr3:95903419-95904033 (-)
CBA/J	MGP_CBAJ_G0020071	protein coding gene	Chr13:22842727-22845019 (-)
DBA/2J	MGP_DBA2J_G0020197	protein coding gene	Chr13:20343084-20344000 (-)
FVB/NJ	MGP_FVBNJ_G0020181	protein coding gene	Chr13:19994745-19995542 (-)
LP/J	MGP_LPJ_G0020270	protein coding gene	Chr13:21515052-21516479 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020208	protein coding gene	Chr13:23135887-23136420 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020792	protein coding gene	Chr13:20921333-20921866 (-)
PWK/PhJ	MGP_PWKPhJ_G0019388	protein coding gene	Chr13:20374759-20375467 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019205	protein coding gene	Chr13:19726947-19727470 (-)
WSB/EiJ	MGP_WSBEiJ_G0019694	protein coding gene	Chr13:21058558-21059926 (-)

Human Ortholog

H3C1, H3 clustered histone 1

Vertebrate Orthologs

13

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

H3C1, H3 clustered histone 1
Synonyms

H3/A, H3C10, H3C11, H3C12, H3C2, H3C3, H3C4, H3C6, H3C7, H3C8, H3FA, HIST1H3A
Links

HGNC:4766

NCBI Gene ID: 8350

neXtProt AC: NX_P68431

UniProt: P68431
Chr Location

6p22.2; chr6:26020451-26020958 (+) GRCh38

Human Ortholog

H3C10, H3 clustered histone 10
Synonyms

H3C1, H3C11, H3C12, H3C2, H3C3, H3C4, H3C6, H3C7, H3C8, H3F1K, H3FK, H3/k, HIST1H3H
Links

HGNC:4775

NCBI Gene ID: 8357

neXtProt AC: NX_P68431

UniProt: P68431
Chr Location

6p22.1; chr6:27810051-27811300 (+) GRCh38

Human Ortholog

H3C11, H3 clustered histone 11
Synonyms

H3C1, H3C10, H3C12, H3C2, H3C3, H3C4, H3C6, H3C7, H3C8, H3.f, H3/f, H3FF, HIST1H3I
Links

HGNC:4771

NCBI Gene ID: 8354

neXtProt AC: NX_P68431

UniProt: P68431
Chr Location

6p22.1; chr6:27871845-27872346 (-) GRCh38

Human Ortholog

H3C2, H3 clustered histone 2
Synonyms

H3C1, H3C10, H3C11, H3C12, H3C3, H3C4, H3C6, H3C7, H3C8, H3FL, H3/l, HIST1H3B
Links

HGNC:4776

NCBI Gene ID: 8358

neXtProt AC: NX_P68431

UniProt: P68431
Chr Location

6p22.2; chr6:26031589-26032099 (-) GRCh38

Human Ortholog

H3C3, H3 clustered histone 3
Synonyms

H3.1, H3/c, H3C1, H3C10, H3C11, H3C12, H3C2, H3C4, H3C6, H3C7, H3C8, H3FC, HIST1H3C
Links

HGNC:4768

NCBI Gene ID: 8352

neXtProt AC: NX_P68431

UniProt: P68431
Chr Location

6p22.2; chr6:26045384-26045869 (+) GRCh38

Human Ortholog

H3C4, H3 clustered histone 4
Synonyms

H3/b, H3C1, H3C10, H3C11, H3C12, H3C2, H3C3, H3C6, H3C7, H3C8, H3FB, HIST1H3D
Links

HGNC:4767

NCBI Gene ID: 8351

neXtProt AC: NX_P68431

UniProt: P68431
Chr Location

6p22.2; chr6:26196784-26199293 (-) GRCh38

Human Ortholog

H3C8, H3 clustered histone 8
Synonyms

H3C1, H3C10, H3C11, H3C12, H3C2, H3C3, H3C4, H3C6, H3C7, H3FH, H3/h, HIST1H3G
Links

HGNC:4772

NCBI Gene ID: 8355

neXtProt AC: NX_P68431

UniProt: P68431
Chr Location

6p22.2; chr6:26270918-26271413 (-) GRCh38

MGI Vertebrate Homology

H3c1 stringent orthology
7 human;1 mouse;3 rat;3 zebrafish
HCOP

vertebrate homology predictions: H3C1, H3C10, H3C11, H3C2, H3C3, H3C4, H3C8
Gene Tree

H3c1

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Phenotype Summary

8 phenotype references

All Mutations and Alleles

2
Chemically induced (other)

1
Radiation induced

1
Genomic Mutations

2 involving H3c1
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

4 strains or lines available

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All GO Annotations

4
GO References

1

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

5
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas

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All Sequences

33
RefSeq

2
UniProt

1
CCDS

CCDS26368.1

Ensembl

ENSMUSG00000069265 (Evidence)
NCBI Gene

360198

			Length	Strain/Species	Flank
genomic	360198	NCBI Gene Model \| MGI Sequence Detail	502	C57BL/6J	± kb
transcript	NM_013550	RefSeq \| MGI Sequence Detail	502	C57BL/6
polypeptide	P68433	UniProt \| EBI \| MGI Sequence Detail	136	Not Applicable

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UniProt

1 Sequence
GlyGen

P68433 1 site, 1 O-linked glycan (1 site)

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All nucleic 6

Genomic 1

cDNA 5

Microarray probesets 3

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MGI:6324962

Summaries

All 33

Developmental Gene Expression 1

Gene Ontology 1

Phenotypes 8
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:357567 Zhang Y, et al., Macrophage MCT4 inhibition activates reparative genes and protects from atherosclerosis by histone H3 lysine 18 lactylation. Cell Rep. 2024 May 28;43(5):114180

TSS for H3c1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr121756	Chr13:23948180-23948203 (-)	-1,823 bp
Tssr121755	Chr13:23947502-23947526 (-)	-1,145 bp
Tssr121754	Chr13:23947485-23947497 (-)	-1,122 bp
Tssr121753	Chr13:23946361-23946374 (-)	1 bp
Tssr121752	Chr13:23946345-23946347 (-)	23 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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