Bsx MGI Mouse Gene Detail - MGI:2669849

Symbol

Bsx
Name

brain specific homeobox
Synonyms

Bsx1a, Bsx1b

Feature Type

protein coding gene
IDs

MGI:2669849
NCBI Gene: 244813
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr9:40785423-40791353 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 21.65 cM
Mapping Data

1 experiment

SNPs within 2kb

216 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2669849	protein coding gene	Chr9:40782994-40791353 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034671	protein coding gene	Chr9:39125938-39129827 (+)
A/J	MGP_AJ_G0034651	protein coding gene	Chr9:38114503-38118392 (+)
AKR/J	MGP_AKRJ_G0034577	protein coding gene	Chr9:38832781-38836668 (+)
BALB/cJ	MGP_BALBcJ_G0034642	protein coding gene	Chr9:37857773-37861662 (+)
C3H/HeJ	MGP_C3HHeJ_G0034353	protein coding gene	Chr9:39358026-39361916 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035165	protein coding gene	Chr9:40370001-40373810 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032078	protein coding gene	Chr9:37740044-37743783 (+)
CAST/EiJ	MGP_CASTEiJ_G0033676	protein coding gene	Chr9:39083884-39087687 (+)
CBA/J	MGP_CBAJ_G0034326	protein coding gene	Chr9:41757493-41761380 (+)
DBA/2J	MGP_DBA2J_G0034485	protein coding gene	Chr9:38047317-38051204 (+)
FVB/NJ	MGP_FVBNJ_G0034425	protein coding gene	Chr9:37271236-37275126 (+)
LP/J	MGP_LPJ_G0034566	protein coding gene	Chr9:39400629-39404516 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034469	protein coding gene	Chr9:43807193-43811081 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035184	protein coding gene	Chr9:38758144-38762031 (+)
PWK/PhJ	MGP_PWKPhJ_G0033381	protein coding gene	Chr9:37859606-37863422 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033217	protein coding gene	Chr9:38985718-38989496 (+)
WSB/EiJ	MGP_WSBEiJ_G0033789	protein coding gene	Chr9:38784439-38788327 (+)

Human Ortholog

BSX, brain specific homeobox

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BSX, brain specific homeobox
Synonyms

BSX1
Links

HGNC:20450

NCBI Gene ID: 390259

neXtProt AC: NX_Q3C1V8

UniProt: Q3C1V8
Chr Location

11q24.1; chr11:122977570-122981834 (-) GRCh38

MGI Vertebrate Homology

Bsx stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: BSX
Gene Tree

Bsx

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Phenotype Summary

14 phenotypes from 4 alleles in 4 genetic backgrounds
8 phenotypes from multigenic genotypes
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

1
Targeted

7
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for mutations in Bsx display increased fat mass, decreased food intake after fasting, decreased body temperature, and reduced locomotor activity, but body weight and glucose homoeostasis are similar to wild-type.

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All GO Annotations

24
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

757
Tissues

30
cDNA Data

7
Literature Summary

11

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA BSX

Xenbase bsx

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All Sequences

32
RefSeq

6
UniProt

1
CCDS

CCDS23084.1

Ensembl

ENSMUSG00000054360 (Evidence)
NCBI Gene

244813

			Length	Strain/Species	Flank
genomic	ENSMUSG00000054360	Ensembl Gene Model \| MGI Sequence Detail	5931	C57BL/6J	± kb
transcript	ENSMUST00000067375	Ensembl \| MGI Sequence Detail	2960	Not Applicable
polypeptide	ENSMUSP00000068057	Ensembl \| MGI Sequence Detail	232	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000004834 brain-specific homeobox protein

(term hierarchy)
InterPro Domains

IPR017970 Homeobox, conserved site

IPR001356 Homeobox domain

IPR050848 Homeobox domain-containing transcription factors

IPR020479 Homeobox domain, metazoa

IPR009057 Homeobox-like domain superfamily

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All nucleic 8

cDNA 7

Other 1

Microarray probesets 1

Summaries

All 38

Developmental Gene Expression 11

Gene Ontology 9

Phenotypes 7
Earliest

J:87378 Cremona M, et al., Bsx, an evolutionary conserved Brain Specific homeoboX gene expressed in the septum, epiphysis, mammillary bodies and arcuate nucleus. Gene Expr Patterns. 2004 Jan;4(1):47-51
Latest

J:330767 Magno L, et al., Fate mapping reveals mixed embryonic origin and unique developmental codes of mouse forebrain septal neurons. Commun Biol. 2022 Oct 27;5(1):1137

TSS for Bsx:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr84489	Chr9:40785277-40785294 (+)	-137 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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