Med13l MGI Mouse Gene Detail - MGI:2670178 - mediator complex subunit 13-like

Symbol

Med13l
Name

mediator complex subunit 13-like
Synonyms

2210413I17Rik, 6330591G05Rik, 9030618F05Rik, mKIAA1025, Thrap2, Trap240L

Feature Type

protein coding gene
IDs

MGI:2670178
NCBI Gene: 76199
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr5:118698744-118903503 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 59.10 cM
Mapping Data

2 experiments

SNPs within 2kb

4170 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2670178	protein coding gene	Chr5:118698363-118903503 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029997	protein coding gene	Chr5:121752863-121966872 (+)
A/J	MGP_AJ_G0029961	protein coding gene	Chr5:116761203-116968560 (+)
AKR/J	MGP_AKRJ_G0029900	protein coding gene	Chr5:120531886-120746693 (+)
BALB/cJ	MGP_BALBcJ_G0029972	protein coding gene	Chr5:118185850-118390829 (+)
C3H/HeJ	MGP_C3HHeJ_G0029692	protein coding gene	Chr5:121069644-121281579 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030427	protein coding gene	Chr5:126370465-126583512 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027653	protein coding gene	Chr5:111515580-111724097 (+)
CAST/EiJ	MGP_CASTEiJ_G0029101	protein coding gene	Chr5:120105693-120322549 (+)
CBA/J	MGP_CBAJ_G0029660	protein coding gene	Chr5:131258117-131494852 (+)
DBA/2J	MGP_DBA2J_G0029810	protein coding gene	Chr5:116866318-117073274 (+)
FVB/NJ	MGP_FVBNJ_G0029766	protein coding gene	Chr5:115761413-115966010 (+)
LP/J	MGP_LPJ_G0029898	protein coding gene	Chr5:122248386-122461151 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029797	protein coding gene	Chr5:135404823-135623967 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030468	protein coding gene	Chr5:120099526-120307713 (+)
PWK/PhJ	MGP_PWKPhJ_G0028814	protein coding gene	Chr5:115586202-115798235 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028652	protein coding gene	Chr5:117698013-117939644 (+)
WSB/EiJ	MGP_WSBEiJ_G0029176	protein coding gene	Chr5:120671335-120880165 (+)

Human Ortholog

MED13L, mediator complex subunit 13L

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MED13L, mediator complex subunit 13L
Synonyms

MRFACD, PROSIT240, THRAP2, TRAP240L
Links

HGNC:22962

NCBI Gene ID: 23389

neXtProt AC: NX_Q71F56

UniProt: Q71F56
Chr Location

12q24.21; chr12:115957905-116277693 (-) GRCh38

MGI Vertebrate Homology

Med13l stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: MED13L
Gene Tree

Med13l

Diseases

1 with human MED13L associations

				Human Disease	Mouse Models
				dextro-looped transposition of the great arteries IDs dextro-looped transposition of the great arteries DOID:0060770 ICD10CM:Q20.3 OMIM:608808 ORDO:860

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

42
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

34
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Med13l
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

111 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

4
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

712
Tissues

4
cDNA Data

138
Literature Summary

3

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase med13l

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All Sequences

69
RefSeq

12
UniProt

6
CCDS

CCDS57375.1, CCDS84948.1

Ensembl

ENSMUSG00000018076 (Evidence)
NCBI Gene

76199

			Length	Strain/Species	Flank
genomic	ENSMUSG00000018076	Ensembl Gene Model \| MGI Sequence Detail	204760	C57BL/6J	± kb
transcript	ENSMUST00000201010	Ensembl \| MGI Sequence Detail	7781	Not Applicable
polypeptide	ENSMUSP00000144092	Ensembl \| MGI Sequence Detail	2216	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000010285 mediator of RNA polymerase II transcription subunit 13-like

(term hierarchy)
InterPro Domains

IPR051139 Mediator complex subunit 13

IPR009401 Mediator complex subunit Med13, C-terminal

IPR021643 Mediator complex, subunit Med13, N-terminal

IPR041285 MID domain of medPIWI

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All nucleic 140

Genomic 2

cDNA 138

Microarray probesets 5

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MGI:1918805, MGI:1922081, MGI:1923449

Summaries

All 56

Developmental Gene Expression 3

Gene Ontology 2

Phenotypes 19
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Med13l:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr48431	Chr5:118698346-118698372 (+)	-385 bp
Tssr48432	Chr5:118698423-118698518 (+)	-273 bp
Tssr48433	Chr5:118698689-118698755 (+)	-22 bp
Tssr48434	Chr5:118699169-118699193 (+)	437 bp
Tssr48435	Chr5:118699204-118699215 (+)	466 bp
Tssr48436	Chr5:118699219-118699237 (+)	484 bp
Tssr48437	Chr5:118737233-118737237 (+)	38,491 bp
Tssr48438	Chr5:118753039-118753042 (+)	54,297 bp
Tssr48439	Chr5:118767006-118767018 (+)	68,268 bp
Tssr48440	Chr5:118775771-118775778 (+)	77,031 bp
Tssr48441	Chr5:118777589-118777593 (+)	78,847 bp
Tssr48442	Chr5:118787656-118787666 (+)	88,917 bp
Tssr48444	Chr5:118903067-118903086 (+)	204,333 bp
Tssr48445	Chr5:118903135-118903164 (+)	204,406 bp
Tssr48446	Chr5:118903248-118903261 (+)	204,511 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24