Tg(HD82Gln)81Gschi
Transgene Detail

Summary

• Symbol: Tg(HD82Gln)81Gschi
• Name: transgene insertion 81, Gabriele Schilling
• MGI ID: MGI:2670626
• Synonyms: HD-N171-82Q, N171-82Q, PrP-htt-N171-82Q, Tg(HD82Gln)81Dbo, TGN(HD82Gln)81Dbo
• Transgene: Tg(HD82Gln)81Gschi Location: unknown
• Alliance: Tg(HD82Gln)81Gschi page

Transgene origin

• Strain of Origin: C3H/B6

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(HD82Gln)81Gschi expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HTT (3064)

  Htt	(MGI:96067)

• Mutation details: This transgenic line expresses an N-terminally truncated human huntingtin cDNA that encodes 82 glutamines and encompasses the first 171 amino acids. The altered huntingtin cDNA is under control of a mouse prion protein promoter, which drives transgene expression in the neurons of the central nervous system (J:53797, J:99630)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:53797 Schilling G, et al., Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin [published erratum appears in Hum Mol Genet 1999 May;8(5):943]. Hum Mol Genet. 1999 Mar;8(3):397-407
• All: 84 reference(s)