Kcnv2 MGI Mouse Gene Detail - MGI:2670981 - potassium channel, subfamily V, member 2

Symbol

Kcnv2
Name

potassium channel, subfamily V, member 2
Synonyms

KV11.1, MGC:38990

Feature Type

protein coding gene
IDs

MGI:2670981
NCBI Gene: 240595
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr19:27299988-27314579 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 21.88 cM
Mapping Data

1 experiment

SNPs within 2kb

545 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2670981	protein coding gene	Chr19:27299461-27314579 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025008	protein coding gene	Chr19:25688182-25702747 (+)
A/J	MGP_AJ_G0024985	protein coding gene	Chr19:24353959-24368627 (+)
AKR/J	MGP_AKRJ_G0024953	protein coding gene	Chr19:25271978-25286607 (+)
BALB/cJ	MGP_BALBcJ_G0024984	protein coding gene	Chr19:24400858-24415809 (+)
C3H/HeJ	MGP_C3HHeJ_G0024740	protein coding gene	Chr19:25241546-25256114 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025425	protein coding gene	Chr19:26425662-26441493 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022844	protein coding gene	Chr19:24379652-24394463 (+)
CAST/EiJ	MGP_CASTEiJ_G0024210	protein coding gene	Chr19:25015902-25031696 (+)
CBA/J	MGP_CBAJ_G0024718	protein coding gene	Chr19:27671903-27686548 (+)
DBA/2J	MGP_DBA2J_G0024850	protein coding gene	Chr19:24329803-24344300 (+)
FVB/NJ	MGP_FVBNJ_G0024812	protein coding gene	Chr19:24179678-24194219 (+)
LP/J	MGP_LPJ_G0024935	protein coding gene	Chr19:25670310-25684881 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024839	protein coding gene	Chr19:27598563-27613182 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025480	protein coding gene	Chr19:25277429-25291983 (+)
PWK/PhJ	MGP_PWKPhJ_G0023958	protein coding gene	Chr19:23974313-23989315 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023762	protein coding gene	Chr19:24493370-24509206 (+)
WSB/EiJ	MGP_WSBEiJ_G0024277	protein coding gene	Chr19:25298316-25312883 (+)

Human Ortholog

KCNV2, potassium voltage-gated channel modifier subfamily V member 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KCNV2, potassium voltage-gated channel modifier subfamily V member 2
Synonyms

KV11.1, Kv8.2, RCD3B
Links

HGNC:19698

NCBI Gene ID: 169522

neXtProt AC: NX_Q8TDN2

UniProt: Q8TDN2
Chr Location

9p24.2; chr9:2717510-2730037 (+) GRCh38

MGI Vertebrate Homology

Kcnv2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: KCNV2
Gene Tree

Kcnv2

Diseases

1 with human KCNV2 associations

				Human Disease	Mouse Models
				retinal cone dystrophy 3B IDs retinal cone dystrophy 3B DOID:0081022 MESH:C563678 OMIM:610356 ORDO:209932

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

9 phenotypes from 2 alleles in 2 genetic backgrounds
6 phenotypes from multigenic genotypes
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

4
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

24 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit loss of photoreceptors with increased apoptosis and defective photopic and scotopic response.

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All GO Annotations

9
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

724
Tissues

13
cDNA Data

13
Literature Summary

4

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN kcnv2a, kcnv2b

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All Sequences

31
RefSeq

4
UniProt

1
CCDS

CCDS29722.1

Ensembl

ENSMUSG00000047298 (Evidence)
NCBI Gene

240595

			Length	Strain/Species	Flank
genomic	ENSMUSG00000047298	Ensembl Gene Model \| MGI Sequence Detail	14592	C57BL/6J	± kb
transcript	ENSMUST00000056708	Ensembl \| MGI Sequence Detail	5108	Not Applicable
polypeptide	ENSMUSP00000055091	Ensembl \| MGI Sequence Detail	562	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000000726 voltage-gated potassium channel KCNV2

(term hierarchy)
InterPro Domains

IPR005821 Ion transport domain

IPR003131 Potassium channel tetramerisation-type BTB domain

IPR003968 Potassium channel, voltage dependent, Kv

IPR003971 Potassium channel, voltage dependent, Kv9

IPR011333 SKP1/BTB/POZ domain superfamily

IPR027359 Voltage-dependent channel domain superfamily
GlyGen

Q8CFS6 1 site

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All nucleic 15

cDNA 14

Primer pair 1

Microarray probesets 2

Summaries

All 35

Developmental Gene Expression 4

Gene Ontology 3

Phenotypes 8
Earliest

J:93300 Blackshaw S, et al., Genomic analysis of mouse retinal development. PLoS Biol. 2004 Oct;2(9):E247
Latest

J:355142 Gomez-Del Arco P, et al., The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and ventricular conduction system development. Nat Commun. 2024 Oct 4;15(1):8602

TSS for Kcnv2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr155737	Chr19:27299159-27299163 (+)	-827 bp
Tssr155738	Chr19:27299918-27299932 (+)	-63 bp
Tssr155739	Chr19:27299939-27299992 (+)	-22 bp
Tssr5470	Chr19:27300000-27300001 (+)	13 bp
Tssr155740	Chr19:27300009-27300017 (+)	25 bp
Tssr155741	Chr19:27312928-27312934 (+)	12,943 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24