In(11Trp53;11Wnt3)8Brd Cytogenetic Marker Detail

Summary

• Symbol
  In(11Trp53;11Wnt3)8Brd
• Name
  inversion, Chr 11, Allan Bradley 8

• Feature Type
  chromosomal inversion
• IDs
  MGI:2673108

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 11, Syntenic
• Mapping Data
  2 experiments

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 1 allele in 1 genetic background
  4 phenotypes from multigenic genotypes
  5 phenotype references
  

• All Mutations and Alleles
  1
• Targeted
  1
• Find Mice (IMSR)
  4 strains or lines available

A 24 cM inversion was created between Trp53 and Wnt3. In the heterozygous state, the inversion serves as a balancer chromosome marked with a K14-agouti transgene. In a homozygous state, the inversion mimics the embryonic lethal phenotype of Wnt3 null mice.

References

• Summaries
  All 7

  Phenotypes 5
• Earliest
  J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
• Latest
  J:174216 Terzian T, et al., Rpl27a mutation in the sooty foot ataxia mouse phenocopies high p53 mouse models. J Pathol. 2011 Aug;224(4):540-52