Tg(IGL-MYC)3Hm
Transgene Detail

Summary

• Symbol: Tg(IGL-MYC)3Hm
• Name: transgene insertion 3, Herbert Morse
• MGI ID: MGI:3619458
• Synonyms: lambda-hu-MYC, lambda-MYC
• Transgene: Tg(IGL-MYC)3Hm Location: unknown
• Alliance: Tg(IGL-MYC)3Hm page

Transgene origin

• Strain of Origin: C57BL/6N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(IGL-MYC)3Hm expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MYC (4609)

  Bmyc	(MGI:88184)
  Myc	(MGI:97250)

• Mutation details: A mutant human MYC gene isolated from a Burkitt lymphoma cell line and characterized by a shift in promoter use from P2 to P1 is fused to a 12 kb human genomic DNA segment containing the intronic enhancer and other functional elements of the IGL locus control region. RT-PCR analysis of various tissues of young, lymphoma-free transgenic mice detects high levels of MYC mRNA in lymphoid tissues, but no or very low levels elsewhere. Immunoblot analysis with human MYC-specific antibodies consistently detects low levels of the protein in spleens of transgenic mice. (J:65245)
• Inheritance: Dominant

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(IGL-MYC)3Hm

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:65245 Kovalchuk AL, et al., Burkitt lymphoma in the mouse. J Exp Med. 2000 Oct 16;192(8):1183-90
• All: 27 reference(s)