Tg(PML-RARA)556Kog
Transgene Detail

Summary

• Symbol: Tg(PML-RARA)556Kog
• Name: transgene insertion 556, Scott Kogan
• MGI ID: MGI:3033300
• Synonyms: hMRP8-PML-RARalpha, MRP8-PMLRARalpha, PML/RARalpha
• Transgene: Tg(PML-RARA)556Kog Location: unknown
• Alliance: Tg(PML-RARA)556Kog page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(PML-RARA)556Kog expresses 2 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PML (5371)

  Pml	(MGI:104662)

  human

  RARA (5914)

  Rara	(MGI:97856)

• Mutation details: The transgene is a human PMLRARalpha cDNA cloned into the hMRP8 expression cassette (MRP8 is a synonym for S100A8, which is S100 calcium binding protein A8 (calgranulin A)). (J:39327)

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Tg(PML-RARA)556Kog

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Line #556 has the highest level of transgene expression of the nine lines created for this study. All mice carrying this transgene on an FVB/N genetic background developed skin papillomas.

References

• Original: J:39327 Brown D, et al., A PMLRARalpha transgene initiates murine acute promyelocytic leukemia. Proc Natl Acad Sci U S A. 1997 Mar 18;94(6):2551-6
• All: 18 reference(s)