Kntc1 MGI Mouse Gene Detail - MGI:2673709

Symbol

Kntc1
Name

kinetochore associated 1
Synonyms

jgl

Feature Type

protein coding gene
IDs

MGI:2673709
NCBI Gene: 208628
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr5:123887779-123959656 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 63.17 cM
Mapping Data

2 experiments

SNPs within 2kb

2030 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2673709	protein coding gene	Chr5:123887755-123959656 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030079	protein coding gene	Chr5:127510393-127583058 (+)
A/J	MGP_AJ_G0030044	protein coding gene	Chr5:122206953-122280704 (+)
AKR/J	MGP_AKRJ_G0029980	protein coding gene	Chr5:126148707-126222180 (+)
BALB/cJ	MGP_BALBcJ_G0030055	protein coding gene	Chr5:123545024-123617456 (+)
C3H/HeJ	MGP_C3HHeJ_G0029772	protein coding gene	Chr5:126757878-126832774 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030508	protein coding gene	Chr5:132451703-132524620 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027734	protein coding gene	Chr5:116756318-116829163 (+)
CAST/EiJ	MGP_CASTEiJ_G0029181	protein coding gene	Chr5:125860713-125934259 (+)
CBA/J	MGP_CBAJ_G0029742	protein coding gene	Chr5:137639886-137716462 (+)
DBA/2J	MGP_DBA2J_G0029892	protein coding gene	Chr5:122222670-122309368 (+)
FVB/NJ	MGP_FVBNJ_G0029848	protein coding gene	Chr5:121265038-121337734 (+)
LP/J	MGP_LPJ_G0029981	protein coding gene	Chr5:128049818-128123581 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029879	protein coding gene	Chr5:141259907-141336602 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030549	protein coding gene	Chr5:125752079-125827336 (+)
PWK/PhJ	MGP_PWKPhJ_G0028895	protein coding gene	Chr5:121042004-121115033 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028732	protein coding gene	Chr5:123418163-123492456 (+)
WSB/EiJ	MGP_WSBEiJ_G0029256	protein coding gene	Chr5:126442938-126516828 (+)

Human Ortholog

KNTC1, kinetochore associated 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KNTC1, kinetochore associated 1
Synonyms

ROD
Links

HGNC:17255

NCBI Gene ID: 9735

neXtProt AC: NX_P50748

UniProt: P50748
Chr Location

12q24.31; chr12:122527246-122626396 (+) GRCh38

MGI Vertebrate Homology

Kntc1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: KNTC1
Gene Tree

Kntc1

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Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
4 images
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

43
Chemically induced (other)

1
Gene trapped

37
Radiation induced

1
Spontaneous

1
Targeted

3
Genomic Mutations

2 involving Kntc1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

111 strains or lines available

Mice have a kinked tail.

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All GO Annotations

23
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

769
Tissues

23
cDNA Data

69
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase kntc1

ZFIN kntc1

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All Sequences

56
RefSeq

15
UniProt

3
CCDS

CCDS39274.1

Ensembl

ENSMUSG00000029414 (Evidence)
NCBI Gene

208628

			Length	Strain/Species	Flank
genomic	ENSMUSG00000029414	Ensembl Gene Model \| MGI Sequence Detail	71878	C57BL/6J	± kb
transcript	ENSMUST00000031366	Ensembl \| MGI Sequence Detail	6961	Not Applicable
polypeptide	ENSMUSP00000031366	Ensembl \| MGI Sequence Detail	2207	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000009431 kinetochore-associated protein 1

(term hierarchy)
InterPro Domains

IPR052802 Kinetochore-associated RZZ complex protein

IPR019527 RZZ complex, subunit KNTC1/ROD, C-terminal

IPR036322 WD40-repeat-containing domain superfamily

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All nucleic 71

cDNA 69

Primer pair 1

Other 1

Microarray probesets 3

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MGI:2667526

Summaries

All 43

Developmental Gene Expression 4

Gene Ontology 5

Phenotypes 16
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Kntc1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr48804	Chr5:123887759-123887798 (+)	0 bp
Tssr48805	Chr5:123947703-123947706 (+)	59,926 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24