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P2ry6 Gene Detail
Summary
  • Symbol
    P2ry6
  • Name
    pyrimidinergic receptor P2Y, G-protein coupled, 6
  • Synonyms
    2010204J23Rik, P2Y6
  • Feature Type
    protein coding gene
  • IDs
    MGI:2673874
    NCBI Gene: 233571
  • Alliance
    gene page
  • Transcription Start Sites
    23 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:100586837-100623856 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 54.46 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1294 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2673874
 protein coding gene Chr7:100586837-100628528 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032579
 protein coding gene Chr7:103861811-103894322 (-)
A/J MGP_AJ_G0032553
 protein coding gene Chr7:101227526-101256302 (-)
AKR/J MGP_AKRJ_G0032489
 protein coding gene Chr7:103637605-103665942 (-)
BALB/cJ MGP_BALBcJ_G0032564
 protein coding gene Chr7:100914972-100942469 (-)
C3H/HeJ MGP_C3HHeJ_G0032279
 protein coding gene Chr7:104029592-104056851 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033062
 protein coding gene Chr7:107795822-107827014 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030056
 protein coding gene Chr7:103614851-103640701 (-)
CAST/EiJ MGP_CASTEiJ_G0031606
 protein coding gene Chr7:95591557-95619233 (-)
CBA/J MGP_CBAJ_G0032246
 protein coding gene Chr7:111508887-111541315 (-)
DBA/2J MGP_DBA2J_G0032397
 protein coding gene Chr7:99560199-99587924 (-)
FVB/NJ MGP_FVBNJ_G0032354
 protein coding gene Chr7:99341847-99369341 (-)
LP/J MGP_LPJ_G0032487
 protein coding gene Chr7:105200506-105228505 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032387
 protein coding gene Chr7:112882800-112911514 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033084
 protein coding gene Chr7:102907057-102939709 (-)
PWK/PhJ MGP_PWKPhJ_G0031324
 protein coding gene Chr7:92679914-92707631 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031167
 protein coding gene Chr7:90217892-90248142 (-)
WSB/EiJ MGP_WSBEiJ_G0031723
 protein coding gene Chr7:103611576-103640399 (-)



Homology
more
  • Human Ortholog
    P2RY6, pyrimidinergic receptor P2Y6
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    P2RY6, pyrimidinergic receptor P2Y6
  • Synonyms
    P2Y6
  • Links
    NCBI Gene ID: 5031
    neXtProt AC: NX_Q15077
    UniProt: Q15077

  • Chr Location
    11q13.4; chr11:73264498-73305103 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 3 genetic backgrounds
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal macrophage, endothelial, and vascular smooth muscle response to UTP and UDP.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    726
  • Tissues
    14
  • cDNA Data
    18
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000048779 Ensembl Gene Model | MGI Sequence Detail 37020 C57BL/6J ±  kb
    transcript ENSMUST00000060174 Ensembl | MGI Sequence Detail 1946 Not Applicable  
    polypeptide ENSMUSP00000055697 Ensembl | MGI Sequence Detail 328 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 18
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1913795
    References
    more
    • Summaries
      All 82
      Developmental Gene Expression 1
      Gene Ontology 8
      Phenotypes 44
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:348027 Umpierre AD, et al., Microglial P2Y(6) calcium signaling promotes phagocytosis and shapes neuroimmune responses in epileptogenesis. Neuron. 2024 Apr 10;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory