Tg(Pbsn-Tag)12T10Rjm
Transgene Detail

Summary

• Symbol: Tg(Pbsn-Tag)12T10Rjm
• Name: transgene insertion 12T10, Robert J Matusik
• MGI ID: MGI:3040284
• Synonyms: 12T-10, Lady, Lady-12-T10, LBP-Tag, Tg(Tag)12T10Rjm
• Transgene: Tg(Pbsn-Tag)12T10Rjm Location: unknown
• Alliance: Tg(Pbsn-Tag)12T10Rjm page

Transgene origin

• Strain of Origin: CD-1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The transgene includes the SV40 large T antigen (Tag) gene, containing a deletion in the early region that eliminates expression of small T antigen, driven by the rat probasin promoter fragment extending from -11500 to +28 bp ("large probasin promoter"). (J:48623)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Pbsn-Tag)12T10Rjm

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Transgenic lines were established and maintained in the CD1 mouse strain.

References

• Original: J:48623 Kasper S, et al., Development, progression, and androgen-dependence of prostate tumors in probasin-large T antigen transgenic mice: a model for prostate cancer [corrected and republished article originally printed in Lab Invest 1998 Mar;78(3):319-33]. Lab Invest. 1998 Jun;78(6):i-xv
• All: 10 reference(s)