Adm2 MGI Mouse Gene Detail - MGI:2675256

Symbol

Adm2
Name

adrenomedullin 2
Synonyms

IMD, intermedin

Feature Type

protein coding gene
IDs

MGI:2675256
NCBI Gene: 223780
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr15:89206923-89208934 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 44.81 cM
Mapping Data

2 experiments

SNPs within 2kb

111 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2675256	protein coding gene	Chr15:89206923-89208934 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022225	protein coding gene	Chr15:90509160-90510916 (+)
A/J	MGP_AJ_G0022184	protein coding gene	Chr15:87047714-87049470 (+)
AKR/J	MGP_AKRJ_G0022159	protein coding gene	Chr15:89622459-89624215 (+)
BALB/cJ	MGP_BALBcJ_G0022190	protein coding gene	Chr15:87154116-87155872 (+)
C3H/HeJ	MGP_C3HHeJ_G0021960	protein coding gene	Chr15:89619525-89621281 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022635	protein coding gene	Chr15:93799336-93801092 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020160	protein coding gene	Chr15:83271901-83273651 (+)
CAST/EiJ	MGP_CASTEiJ_G0021482	protein coding gene	Chr15:90394839-90396575 (+)
CBA/J	MGP_CBAJ_G0021927	protein coding gene	Chr15:96975456-96977212 (+)
DBA/2J	MGP_DBA2J_G0022054	protein coding gene	Chr15:86499768-86501524 (+)
FVB/NJ	MGP_FVBNJ_G0022033	protein coding gene	Chr15:85565800-85567556 (+)
LP/J	MGP_LPJ_G0022125	protein coding gene	Chr15:90669331-90671087 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022053	protein coding gene	Chr15:101378778-101380534 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022650	protein coding gene	Chr15:89662619-89664375 (+)
PWK/PhJ	MGP_PWKPhJ_G0021223	protein coding gene	Chr15:86561020-86562772 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021057	protein coding gene	Chr15:89400708-89402461 (+)
WSB/EiJ	MGP_WSBEiJ_G0021531	protein coding gene	Chr15:90148612-90150368 (+)

Human Ortholog

ADM2, adrenomedullin 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ADM2, adrenomedullin 2
Synonyms

AM2, dJ579N16.4
Links

HGNC:28898

NCBI Gene ID: 79924

neXtProt AC: NX_Q7Z4H4

UniProt: Q7Z4H4
Chr Location

22q13.33; chr22:50481543-50486440 (+) GRCh38

MGI Vertebrate Homology

Adm2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ADM2
Gene Tree

Adm2

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References

1 with disease annotations

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Phenotype Summary

16 phenotypes from 2 alleles in 2 genetic backgrounds
34 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

4
Radiation induced

2
Targeted

5
Genomic Mutations

3 involving Adm2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

11 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit shrinkage of the brush border, perivascular cuffing and vacuole degeneration in the lungs and kidney, macrophage infiltration in the liver, increased vascular leakage, and increased susceptibility to surgery-induced sepsis.

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All GO Annotations

19
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

709
Tissues

3
cDNA Data

4
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN adm2a

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All Sequences

33
RefSeq

2
UniProt

1
CCDS

CCDS27744.1

Ensembl

ENSMUSG00000054136 (Evidence)
NCBI Gene

223780

			Length	Strain/Species	Flank
genomic	223780	NCBI Gene Model \| MGI Sequence Detail	2012	C57BL/6J	± kb
transcript	NM_182928	RefSeq \| MGI Sequence Detail	1300	C57BL/6
polypeptide	Q7TNK8	UniProt \| EBI \| MGI Sequence Detail	150	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000003782 protein ADM2

(term hierarchy)
InterPro Domains

IPR051665 Adrenomedullin-regulatory peptide

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All nucleic 6

Genomic 2

cDNA 4

Microarray probesets 2

Summaries

All 73

Developmental Gene Expression 2

Diseases 1

Gene Ontology 7

Phenotypes 34
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:352715 Kang HS, et al., GLIS3 expression in the thyroid gland in relation to TSH signaling and regulation of gene expression. Cell Mol Life Sci. 2024 Jan 28;81(1):65

TSS for Adm2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr132654	Chr15:89207132-89207163 (+)	225 bp
Tssr132655	Chr15:89207172-89207189 (+)	258 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24