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Tnfrsf14 Gene Detail
Summary
  • Symbol
    Tnfrsf14
  • Name
    tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
  • Synonyms
    Atar, HveA, Hvem
  • Feature Type
    protein coding gene
  • IDs
    MGI:2675303
    NCBI Gene: 230979
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:155006390-155013020 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 85.81 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    322 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2675303
 protein coding gene Chr4:155002944-155013077 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029202
 protein coding gene Chr4:159207141-159213498 (-)
A/J MGP_AJ_G0029167
 protein coding gene Chr4:152525561-152531957 (-)
AKR/J MGP_AKRJ_G0029115
 protein coding gene Chr4:156683741-156690098 (-)
BALB/cJ MGP_BALBcJ_G0029183
 protein coding gene Chr4:152994216-153000577 (-)
C3H/HeJ MGP_C3HHeJ_G0028904
 protein coding gene Chr4:157220903-157227259 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029632
 protein coding gene Chr4:164896443-164902796 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026878
 protein coding gene Chr4:144824107-144834329 (-)
CAST/EiJ MGP_CASTEiJ_G0028317
 protein coding gene Chr4:154643942-154653918 (-)
CBA/J MGP_CBAJ_G0028866
 protein coding gene Chr4:169836653-169843003 (-)
DBA/2J MGP_DBA2J_G0029015
 protein coding gene Chr4:152550596-152556986 (-)
FVB/NJ MGP_FVBNJ_G0028979
 protein coding gene Chr4:151773840-151780192 (-)
LP/J MGP_LPJ_G0029105
 protein coding gene Chr4:159132785-159139142 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029006
 protein coding gene Chr4:172717725-172724076 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029664
 protein coding gene Chr4:157275707-157282060 (-)
PWK/PhJ MGP_PWKPhJ_G0028037
 protein coding gene Chr4:148670640-148679013 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027871
 protein coding gene Chr4:151556485-151564673 (-)
WSB/EiJ MGP_WSBEiJ_G0028397
 protein coding gene Chr4:157443381-157449735 (-)



Homology
more
  • Human Ortholog
    TNFRSF14, TNF receptor superfamily member 14
  • Vertebrate Orthologs
    8
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TNFRSF14, TNF receptor superfamily member 14
  • Synonyms
    ATAR, CD270, HVEA, HVEM, LIGHTR, TR2
  • Links
    NCBI Gene ID: 8764
    neXtProt AC: NX_Q92956
    UniProt: Q92956

  • Chr Location
    1p36.32; chr1:2554234-2565382 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 5 alleles in 5 genetic backgrounds
    1 phenotype from multigenic genotypes
    50 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele are less susceptible to induced colitis. Homozygotes for a second null allele exhibit enhanced responses to various T cell stimuli and are more susceptible to developing autoimmune diseases. Homozygotes for a third null allele show reduced length of allograft survival.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    727
  • Tissues
    1
  • cDNA Data
    7
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042333 Ensembl Gene Model | MGI Sequence Detail 6631 C57BL/6J ±  kb
    transcript ENSMUST00000219534 Ensembl | MGI Sequence Detail 1173 Not Applicable  
    polypeptide ENSMUSP00000151575 Ensembl | MGI Sequence Detail 276 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 7

      Microarray probesets 2
    References
    more
    • Summaries
      All 83
      Developmental Gene Expression 1
      Gene Ontology 7
      Phenotypes 50
    • Earliest
      J:40487 Hsu H, et al., ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5. J Biol Chem. 1997 May 23;272(21):13471-4
    • Latest
      J:337669 Seo GY, et al., Epithelial HVEM maintains intraepithelial T cell survival and contributes to host protection. Sci Immunol. 2022 Jul 29;7(73):eabm6931
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory