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Nanos3 Gene Detail
Summary
  • Symbol
    Nanos3
  • Name
    nanos C2HC-type zinc finger 3
  • Synonyms
    nos3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2675387
    NCBI Gene: 244551
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:84900359-84911396 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 40.45 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    313 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2675387
 protein coding gene Chr8:84900359-84911846 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033858
 protein coding gene Chr8:85048385-85051215 (-)
A/J MGP_AJ_G0033841
 protein coding gene Chr8:81715767-81719545 (-)
AKR/J MGP_AKRJ_G0033767
 protein coding gene Chr8:84131480-84134310 (-)
BALB/cJ MGP_BALBcJ_G0033834
 protein coding gene Chr8:81822964-81825794 (-)
C3H/HeJ MGP_C3HHeJ_G0033544
 protein coding gene Chr8:84742043-84745791 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034354
 protein coding gene Chr8:88315543-88318362 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031296
 protein coding gene Chr8:75514551-75518199 (-)
CAST/EiJ MGP_CASTEiJ_G0032874
 protein coding gene Chr8:84167433-84170264 (-)
CBA/J MGP_CBAJ_G0033520
 protein coding gene Chr8:91417604-91420573 (-)
DBA/2J MGP_DBA2J_G0033674
 protein coding gene Chr8:81355370-81358440 (-)
FVB/NJ MGP_FVBNJ_G0033621
 protein coding gene Chr8:80281740-80284559 (-)
LP/J MGP_LPJ_G0033765
 protein coding gene Chr8:85157020-85159850 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033663
 protein coding gene Chr8:93926035-93928954 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034371
 protein coding gene Chr8:84112640-84115459 (-)
PWK/PhJ MGP_PWKPhJ_G0032578
 protein coding gene Chr8:80581116-80583934 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032414
 protein coding gene Chr8:82921907-82924749 (-)
WSB/EiJ MGP_WSBEiJ_G0032987
 protein coding gene Chr8:84521075-84523990 (-)



Homology
more
  • Human Ortholog
    NANOS3, nanos C2HC-type zinc finger 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NANOS3, nanos C2HC-type zinc finger 3
  • Synonyms
    NANOS1L, NOS3, ZC2HC12C
  • Links
    NCBI Gene ID: 342977
    neXtProt AC: NX_P60323
    UniProt: P60323

  • Chr Location
    19p13.12; chr19:13862036-13880757 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    9 phenotypes from multigenic genotypes
    65 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this locus results in both male and female infertility. Both male and female gonads are reduced in size and are devoid of germ cells, putatively due to impaired maintainence of primordial germ cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    773
  • Tissues
    27
  • cDNA Data
    7
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 244551 NCBI Gene Model | MGI Sequence Detail 11038 C57BL/6J ±  kb
    transcript NM_194059 RefSeq | MGI Sequence Detail 730 C57BL/6  
    polypeptide P60324 UniProt | EBI | MGI Sequence Detail 178 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 7
      Primer pair 3

      Microarray probesets 1
    References
    more
    • Summaries
      All 98
      Developmental Gene Expression 16
      Gene Ontology 10
      Phenotypes 65
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
    • Latest
      J:347251 Mikami N, et al., Deletion of Exoc7, but not Exoc3, in male germ cells causes severe spermatogenesis failure with spermatocyte aggregation in mice. Exp Anim. 2024 Feb 7;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory