Nusap1 MGI Mouse Gene Detail - MGI:2675669 - nucleolar and spindle associated protein 1

Symbol

Nusap1
Name

nucleolar and spindle associated protein 1
Synonyms

2610201A12Rik, NuSAP

Feature Type

protein coding gene
IDs

MGI:2675669
NCBI Gene: 108907
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr2:119449205-119480646 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 59.97 cM
Mapping Data

2 experiments

SNPs within 2kb

812 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2675669	protein coding gene	Chr2:119448779-119481725 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026347	protein coding gene	Chr2:122432790-122469965 (+)
A/J	MGP_AJ_G0026308	protein coding gene	Chr2:117419366-117455851 (+)
AKR/J	MGP_AKRJ_G0026287	protein coding gene	Chr2:120699625-120737289 (+)
BALB/cJ	MGP_BALBcJ_G0026321	protein coding gene	Chr2:117665100-117700047 (+)
C3H/HeJ	MGP_C3HHeJ_G0026067	protein coding gene	Chr2:121161478-121201074 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026768	protein coding gene	Chr2:126420923-126456977 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024148	protein coding gene	Chr2:112455619-112486456 (+)
CAST/EiJ	MGP_CASTEiJ_G0025529	protein coding gene	Chr2:121481094-121518189 (+)
CBA/J	MGP_CBAJ_G0026043	protein coding gene	Chr2:130862335-130899755 (+)
DBA/2J	MGP_DBA2J_G0026182	protein coding gene	Chr2:116820702-116856021 (+)
FVB/NJ	MGP_FVBNJ_G0026144	protein coding gene	Chr2:115651177-115685180 (+)
LP/J	MGP_LPJ_G0026283	protein coding gene	Chr2:122698934-122735692 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026163	protein coding gene	Chr2:135188895-135224138 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026823	protein coding gene	Chr2:120814982-120852478 (+)
PWK/PhJ	MGP_PWKPhJ_G0025265	protein coding gene	Chr2:116405217-116438962 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025064	protein coding gene	Chr2:120011288-120028380 (+)
WSB/EiJ	MGP_WSBEiJ_G0025598	protein coding gene	Chr2:121651709-121689663 (+)

Human Ortholog

NUSAP1, nucleolar and spindle associated protein 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NUSAP1, nucleolar and spindle associated protein 1
Synonyms

ANKT, BM037, LNP, NUSAP, PRO0310p1, Q0310, SAPL
Links

HGNC:18538

NCBI Gene ID: 51203

neXtProt AC: NX_Q9BXS6

UniProt: Q9BXS6
Chr Location

15q15.1; chr15:41320794-41381050 (+) GRCh38

MGI Vertebrate Homology

Nusap1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NUSAP1
Gene Tree

Nusap1

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

38
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

30
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Nusap1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

37 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Early embryos homozygous for a knock-out allele are small and exhibit disorganized embryonic tissue, abnormal chromatin-induced spindle assembly, abnormal inner cell mass apoptosis, and complete embryonic lethality at implantation.

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All GO Annotations

18
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

830
Tissues

82
cDNA Data

19
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nusap1

ZFIN nusap1

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All Sequences

57
RefSeq

6
UniProt

1
CCDS

CCDS16605.1, CCDS38206.1

Ensembl

ENSMUSG00000027306 (Evidence)
NCBI Gene

108907

			Length	Strain/Species	Flank
genomic	108907	NCBI Gene Model \| MGI Sequence Detail	31442	C57BL/6J	± kb
transcript	NM_133851	RefSeq \| MGI Sequence Detail	2146	C57BL/6
polypeptide	Q9ERH4	UniProt \| EBI \| MGI Sequence Detail	427	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000011531 nucleolar and spindle-associated protein 1

(term hierarchy)
InterPro Domains

IPR026756 Nucleolar and spindle-associated protein 1

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All nucleic 21

cDNA 19

Primer pair 1

Other 1

Microarray probesets 7

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MGI:1919720, MGI:2138984, MGI:2139379, MGI:2139440

Summaries

All 45

Developmental Gene Expression 7

Gene Ontology 4

Phenotypes 14
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:349860 Hashimoto K, et al., Loss of connectin novex-3 leads to heart dysfunction associated with impaired cardiomyocyte proliferation and abnormal nuclear mechanics. Sci Rep. 2024 Jun 14;14(1):13727

TSS for Nusap1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr19645	Chr2:119449202-119449218 (+)	5 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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