Tg(Pbsn-MYC)6Key
Transgene Detail

Summary

• Symbol: Tg(Pbsn-MYC)6Key
• Name: transgene insertion 6, Charles L Sawyers
• MGI ID: MGI:3619445
• Synonyms: Lo-Myc, PB-Myc-PAI
• Transgene: Tg(Pbsn-MYC)6Key Location: unknown
• Alliance: Tg(Pbsn-MYC)6Key page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Pbsn-MYC)6Key expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MYC (4609)

  Bmyc	(MGI:88184)
  Myc	(MGI:97250)

• Mutation details: Nucleotides -426 through +28 of the rat probasin gene, containing its androgen-inducible, prostate-specific promoter, were joined to a human MYC cDNA flanked by a FLAG epitope coding sequence and the polyadenylation signal from the insulin receptor gene. Immunoblot analysis with an antibody specific for human MYC demonstrates expression in prostate of mice as young as two weeks of age, which increases as the mice approach puberty at approximately 4 weeks. (J:85480)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Pbsn-MYC)6Key

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:85480 Ellwood-Yen K, et al., Myc-driven murine prostate cancer shares molecular features with human prostate tumors. Cancer Cell. 2003 Sep;4(3):223-38
• All: 6 reference(s)