Tg(ARR2/Pbsn-MYC)7Key
Transgene Detail

Summary

• Symbol: Tg(ARR2/Pbsn-MYC)7Key
• Name: transgene insertion 7, Katharine Ellwood-Yen
• MGI ID: MGI:3785495
• Synonyms: ARR2PB-Myc-PAI, ARR2/probasin-Myc, Hi-Myc, Tg(Pbsn-MYC)4Key
• Transgene: Tg(ARR2/Pbsn-MYC)7Key Location: unknown
• Alliance: Tg(ARR2/Pbsn-MYC)7Key page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(ARR2/Pbsn-MYC)7Key expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MYC (4609)

  Bmyc	(MGI:88184)
  Myc	(MGI:97250)

• Mutation details: Nucleotides -426 through +28 of the rat probasin gene, containing its androgen-inducible, prostate-specific promoter with 2 additional androgen-inducible elements, were joined to a human MYC cDNA flanked by a FLAG epitope coding sequence and the poly-adenylation signal from the insulin receptor gene. Immunoblot analysis with an antibody specific for human MYC demonstrates expression in prostate of mice as young as two weeks of age, which increases as the mice approach puberty at approximately 4 weeks. Four founder lines were established (4, 7, 11 and 13) since no distinction was made between the lines, line 7 was chosen as the representative line. (J:85480)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(ARR2/Pbsn-MYC)7Key

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:85480 Ellwood-Yen K, et al., Myc-driven murine prostate cancer shares molecular features with human prostate tumors. Cancer Cell. 2003 Sep;4(3):223-38
• All: 52 reference(s)