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Muc19 Gene Detail
Summary
  • Symbol
    Muc19
  • Name
    mucin 19
  • Synonyms
    apomucin, sld
  • Feature Type
    protein coding gene
  • IDs
    MGI:2676278
    NCBI Gene: 239611
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:91722531-91832440 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 46.14 cM, cytoband E3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2356 from dbSNP Build 142
  • Strain Annotations
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2676278
 protein coding gene Chr15:91722531-91832447 (+)
129S1/SvImJ no annotation
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    MUC19, mucin 19, oligomeric (gene/pseudogene)
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MUC19, mucin 19, oligomeric (gene/pseudogene)
  • Synonyms
    MUC-19
  • Links
    NCBI Gene ID: 283463
    neXtProt AC: NX_Q7Z5P9
    UniProt: Q7Z5P9

  • Chr Location
    12q12; chr12:40393394-40570832 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Muc19 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    1 images
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for this spontaneous mutation show a partially arrested mucous cell differentiation of the sublingual glands. Severe inflammatory lesions resembling Sjogren's syndrome develop spontaneously in salivary and lacrimal glands of neonatally thymectomized mutants without any immunization.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    65
  • Tissues
    11
  • cDNA Data
    5
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Other Mouse Links
      GEO
    • Other Vertebrate Links
      Xenbase muc19
    Sequences &
    Gene Models
    less
    • All Sequences
      31
    • RefSeq
      2
    • UniProt
      6
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 239611 NCBI Gene Model | MGI Sequence Detail 109910 C57BL/6J ±  kb
    transcript NM_207243 RefSeq | MGI Sequence Detail 22793 C57BL/6  
    polypeptide Q6PZE0 UniProt | EBI | MGI Sequence Detail 7524 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • InterPro Domains
      IPR006207 Cystine knot, C-terminal
      IPR029034 Cystine-knot cytokine
      IPR006208 Glycoprotein hormone subunit beta
      IPR050780 Mucin/von Willebrand/Thrombospondin superfamily
      IPR036084 Serine protease inhibitor-like superfamily
      IPR002919 Trypsin Inhibitor-like, cysteine rich domain
      IPR001846 von Willebrand factor, type D domain
      IPR001007 VWFC domain
      IPR014853 VWF/SSPO/Zonadhesin-like, cysteine-rich domain
    Molecular
    Reagents
    less
    • All nucleic 11
      Genomic 1
      cDNA 5
      Primer pair 5

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-14437, MGI:98316
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 4
      Diseases 5
      Gene Ontology 14
      Phenotypes 43
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:346457 Gao X, et al., Nkx2.3 transcription factor is a key regulator of mucous cell identity in salivary glands. Dev Biol. 2024 May;509:1-10
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory