Gramd4 MGI Mouse Gene Detail - MGI:2676308

Symbol

Gramd4
Name

GRAM domain containing 4

Feature Type

protein coding gene
IDs

MGI:2676308
NCBI Gene: 223752
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr15:85941896-86021835 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 40.48 cM
Mapping Data

1 experiment

SNPs within 2kb

2338 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2676308	protein coding gene	Chr15:85941896-86021837 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022201	protein coding gene	Chr15:87010097-87090948 (+)
A/J	MGP_AJ_G0022160	protein coding gene	Chr15:83736515-83819268 (+)
AKR/J	MGP_AKRJ_G0022135	protein coding gene	Chr15:86205954-86290599 (+)
BALB/cJ	MGP_BALBcJ_G0022166	protein coding gene	Chr15:83861776-83944279 (+)
C3H/HeJ	MGP_C3HHeJ_G0021936	protein coding gene	Chr15:86154717-86239303 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022611	protein coding gene	Chr15:90235280-90317471 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020136	protein coding gene	Chr15:80048858-80127773 (+)
CAST/EiJ	MGP_CASTEiJ_G0021458	protein coding gene	Chr15:86975184-87062587 (+)
CBA/J	MGP_CBAJ_G0021903	protein coding gene	Chr15:93267265-93358763 (+)
DBA/2J	MGP_DBA2J_G0022030	protein coding gene	Chr15:83193882-83275079 (+)
FVB/NJ	MGP_FVBNJ_G0022009	protein coding gene	Chr15:82275490-82359487 (+)
LP/J	MGP_LPJ_G0022101	protein coding gene	Chr15:87152195-87236309 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022029	protein coding gene	Chr15:97898452-97991538 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022626	protein coding gene	Chr15:86232643-86316763 (+)
PWK/PhJ	MGP_PWKPhJ_G0021199	protein coding gene	Chr15:83215058-83298704 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021033	protein coding gene	Chr15:85928445-86022722 (+)
WSB/EiJ	MGP_WSBEiJ_G0021507	protein coding gene	Chr15:86712322-86795698 (+)

Human Ortholog

GRAMD4, GRAM domain containing 4

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GRAMD4, GRAM domain containing 4
Synonyms

DIP
Links

HGNC:29113

NCBI Gene ID: 23151

neXtProt AC: NX_Q6IC98

UniProt: Q6IC98
Chr Location

22q13.31; chr22:46575744-46682756 (+) GRCh38

MGI Vertebrate Homology

Gramd4 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: GRAMD4
Gene Tree

Gramd4

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References

1 with disease annotations

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Phenotype Summary

27 phenotype references

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

2
Radiation induced

2
Targeted

2
Genomic Mutations

3 involving Gramd4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

33 strains or lines available

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All GO Annotations

9
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

778
Tissues

17
cDNA Data

86
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gramd4

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All Sequences

58
RefSeq

15
UniProt

4
CCDS

CCDS27727.1, CCDS56998.1

Ensembl

ENSMUSG00000035900 (Evidence)
NCBI Gene

223752

			Length	Strain/Species	Flank
genomic	ENSMUSG00000035900	Ensembl Gene Model \| MGI Sequence Detail	79940	C57BL/6J	± kb
transcript	ENSMUST00000088931	Ensembl \| MGI Sequence Detail	4115	Not Applicable
polypeptide	ENSMUSP00000086321	Ensembl \| MGI Sequence Detail	633	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000008218 GRAM domain-containing protein 4

(term hierarchy)
InterPro Domains

IPR037845 GRAMDC4, PH-GRAM domain

IPR004182 GRAM domain

IPR037847 GRAM domain-containing protein 4

IPR011993 PH-like domain superfamily

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All nucleic 88

cDNA 87

Primer pair 1

Microarray probesets 3

Summaries

All 54

Developmental Gene Expression 3

Diseases 1

Gene Ontology 5

Phenotypes 27
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:285676 Suzuki A, et al., Genes and microRNAs associated with mouse cleft palate: A systematic review and bioinformatics analysis. Mech Dev. 2018 Apr;150:21-27

TSS for Gramd4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr132563	Chr15:85942947-85942994 (+)	1,075 bp
Tssr132564	Chr15:85942997-85943052 (+)	1,129 bp
Tssr132565	Chr15:85951907-85951945 (+)	10,030 bp
Tssr132566	Chr15:85952017-85952054 (+)	10,140 bp
Tssr132567	Chr15:85958992-85959011 (+)	17,106 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24