Plekhg1 MGI Mouse Gene Detail - MGI:2676551 - pleckstrin homology domain containing, family G (with RhoGef domain) member 1

Symbol

Plekhg1
Name

pleckstrin homology domain containing, family G (with RhoGef domain) member 1
Synonyms

D10Ertd733e, mKIAA1209

Feature Type

protein coding gene
IDs

MGI:2676551
NCBI Gene: 213783
Alliance

gene page
Transcription Start Sites

20 TSS

Sequence Map

Chr10:3690364-3917303 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 2.06 cM
Mapping Data

3 experiments

SNPs within 2kb

6448 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2676551	protein coding gene	Chr10:3690206-3917303 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016974	protein coding gene	Chr10:670503-918708 (+)
A/J	MGP_AJ_G0016952	protein coding gene	Chr10:644819-884332 (+)
AKR/J	MGP_AKRJ_G0016917	protein coding gene	Chr10:615331-858179 (+)
BALB/cJ	MGP_BALBcJ_G0016910	protein coding gene	Chr10:615025-846066 (+)
C3H/HeJ	MGP_C3HHeJ_G0016735	protein coding gene	Chr10:688778-932648 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017373	protein coding gene	Chr10:664706-915501 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015079	protein coding gene	Chr10:502584-722300 (+)
CAST/EiJ	MGP_CASTEiJ_G0016317	protein coding gene	Chr10:716106-959190 (+)
CBA/J	MGP_CBAJ_G0016707	protein coding gene	Chr10:664700-925689 (+)
DBA/2J	MGP_DBA2J_G0016815	protein coding gene	Chr10:657794-884300 (+)
FVB/NJ	MGP_FVBNJ_G0016810	protein coding gene	Chr10:611343-840199 (+)
LP/J	MGP_LPJ_G0016890	protein coding gene	Chr10:675197-928237 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016841	protein coding gene	Chr10:671669-909894 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017410	protein coding gene	Chr10:630885-869765 (+)
PWK/PhJ	MGP_PWKPhJ_G0016103	protein coding gene	Chr10:641188-877748 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015884	protein coding gene	Chr10:817536-1063109 (+)
WSB/EiJ	MGP_WSBEiJ_G0016378	protein coding gene	Chr10:659585-905548 (+)

Human Ortholog

PLEKHG1, pleckstrin homology and RhoGEF domain containing G1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PLEKHG1, pleckstrin homology and RhoGEF domain containing G1
Synonyms

ARHGEF41
Links

HGNC:20884

NCBI Gene ID: 57480

neXtProt AC: NX_Q9ULL1

UniProt: Q9ULL1
Chr Location

6q25.1; chr6:150599883-150843665 (+) GRCh38

MGI Vertebrate Homology

Plekhg1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: PLEKHG1
Gene Tree

Plekhg1

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

1
Gene trapped

8
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

64 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

3
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

721
Tissues

11
cDNA Data

17
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA PLEKHG1

Xenbase plekhg1

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All Sequences

81
RefSeq

15
UniProt

12
CCDS

CCDS56671.1

Ensembl

ENSMUSG00000040624 (Evidence)
NCBI Gene

213783

			Length	Strain/Species	Flank
genomic	ENSMUSG00000040624	Ensembl Gene Model \| MGI Sequence Detail	226940	C57BL/6J	± kb
transcript	ENSMUST00000239159	Ensembl \| MGI Sequence Detail	4478	Not Applicable
polypeptide	ENSMUSP00000159056	Ensembl \| MGI Sequence Detail	1465	Not Applicable

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UniProt

12 Sequences
InterPro Domains

IPR000219 Dbl homology (DH) domain

IPR035899 Dbl homology (DH) domain superfamily

IPR011993 PH-like domain superfamily

IPR043324 PKHG1/2/3, pleckstrin homology (PH) domain

IPR001849 Pleckstrin homology domain

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All nucleic 20

cDNA 17

Primer pair 3

Microarray probesets 4

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MGI:1289304

Summaries

All 39

Developmental Gene Expression 7

Gene Ontology 2

Phenotypes 9
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:352993 Krishnamurthy A, et al., Engrailed transcription factors direct excitatory cerebellar neuron diversity and survival. Development. 2024 Jul 15;151(14):dev202502

TSS for Plekhg1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr92214	Chr10:3690253-3690271 (+)	-102 bp
Tssr92215	Chr10:3690348-3690430 (+)	25 bp
Tssr92216	Chr10:3690453-3690486 (+)	106 bp
Tssr92217	Chr10:3690644-3690671 (+)	294 bp
Tssr3110	Chr10:3708392-3708400 (+)	18,032 bp
Tssr92218	Chr10:3738895-3738899 (+)	48,533 bp
Tssr92219	Chr10:3739377-3739378 (+)	49,014 bp
Tssr92220	Chr10:3784876-3784904 (+)	94,526 bp
Tssr92221	Chr10:3784911-3784928 (+)	94,556 bp
Tssr3111	Chr10:3809666-3809673 (+)	119,306 bp
Tssr92222	Chr10:3809680-3809690 (+)	119,321 bp
Tssr92223	Chr10:3809736-3809774 (+)	119,391 bp
Tssr92224	Chr10:3813689-3813706 (+)	123,334 bp
Tssr92225	Chr10:3813793-3813811 (+)	123,438 bp
Tssr92226	Chr10:3813818-3813842 (+)	123,466 bp
Tssr92227	Chr10:3813851-3813866 (+)	123,495 bp
Tssr92228	Chr10:3813880-3813889 (+)	123,521 bp
Tssr92229	Chr10:3822780-3822788 (+)	132,420 bp
Tssr92230	Chr10:3822806-3822818 (+)	132,448 bp
Tssr92231	Chr10:3824659-3824668 (+)	134,300 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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