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Mir10b Gene Detail
Summary
  • Symbol
    Mir10b
  • Name
    microRNA 10b
  • Synonyms
    mir-10b, Mirn10b, mmu-mir-10b
  • Feature Type
    miRNA gene
  • IDs
    MGI:2676804
    NCBI Gene: 387144
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr2:74556414-74556481 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 44.13 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    44 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2676804
 miRNA gene Chr2:74556414-74556481 (+)
129S1/SvImJ MGP_129S1SvImJ_G0008554
 miRNA gene Chr2:75039869-75039936 (+)
A/J MGP_AJ_G0008542
 miRNA gene Chr2:72107155-72107222 (+)
AKR/J MGP_AKRJ_G0008527
 miRNA gene Chr2:74060519-74060586 (+)
BALB/cJ MGP_BALBcJ_G0008530
 miRNA gene Chr2:72294480-72294547 (+)
C3H/HeJ MGP_C3HHeJ_G0008470
 miRNA gene Chr2:74248621-74248688 (+)
C57BL/6NJ MGP_C57BL6NJ_G0008738
 miRNA gene Chr2:77276924-77276991 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0007724
 miRNA gene Chr2:69530580-69530647 (+)
CAST/EiJ MGP_CASTEiJ_G0008327
 miRNA gene Chr2:74565651-74565718 (+)
CBA/J MGP_CBAJ_G0008435
 miRNA gene Chr2:80099748-80099815 (+)
DBA/2J MGP_DBA2J_G0008473
 miRNA gene Chr2:71714650-71714717 (+)
FVB/NJ MGP_FVBNJ_G0008490
 miRNA gene Chr2:71103147-71103214 (+)
LP/J MGP_LPJ_G0008561
 miRNA gene Chr2:74904221-74904288 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0008452
 miRNA gene Chr2:82010626-82010693 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0008726
 miRNA gene Chr2:74177040-74177107 (+)
PWK/PhJ MGP_PWKPhJ_G0008254
 miRNA gene Chr2:71645166-71645233 (+)
SPRET/EiJ MGP_SPRETEiJ_G0008111
 miRNA gene Chr2:74409713-74409780 (+)
WSB/EiJ MGP_WSBEiJ_G0008414
 miRNA gene Chr2:74614755-74614822 (+)



Homology
more
  • Human Ortholog
    MIR10B, microRNA 10b
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MIR10B, microRNA 10b
  • Synonyms
    hsa-mir-10b, mir-10b, MIRN10B, miRNA10B
  • Links
    NCBI Gene ID: 406903

  • Chr Location
    chr2:176150303-176150412 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit hyperglycemia, impaired glucose tolerance, insulin resistance, gut dysmobility, gut barrier dysfunction, and colon inflammation. Mice homozygous for a reporter allele are viable with no observed pathologies.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    709
  • Tissues
    3
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      24
    • RefSeq
      1
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 387144 NCBI Gene Model | MGI Sequence Detail 68 C57BL/6J ±  kb
    transcript NR_029566 RefSeq | MGI Sequence Detail 68 C57BL/6  
    For the selected sequence
    Molecular
    Reagents
    less
    • All nucleic 2
      Other 2
    Other Database
    Links
    less
    miRBase MI0000221
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 8
      Gene Ontology 3
      Phenotypes 41
    • Earliest
      J:10491 Davisson MT, et al., The mouse mutation ulnaless on chromosome 2. J Hered. 1990 Mar-Apr;81(2):151-3
    • Latest
      J:356218 Szakats S, et al., Sex-biased gene and microRNA expression in the developing mouse brain is associated with neurodevelopmental functions and neurological phenotypes. Biol Sex Differ. 2023 Sep 7;14(1):57
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory