Mir122 MGI Mouse Gene Detail - MGI:2676805

Symbol

Mir122
Name

microRNA 122
Synonyms

Mir122a, Mir122b, Mirn122a, Mirn122b, mmu-mir-122, mmu-mir-122a

Feature Type

miRNA gene
IDs

MGI:2676805
NCBI Gene: 387231
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr18:65381932-65381997 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18,
Mapping Data

1 experiment

SNPs within 2kb

145 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2676805	miRNA gene	Chr18:65381932-65381997 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0008397	miRNA gene	Chr18:65369797-65369862 (+)
A/J	MGP_AJ_G0008386	miRNA gene	Chr18:62544224-62544289 (+)
AKR/J	MGP_AKRJ_G0008370	miRNA gene	Chr18:64302299-64302364 (+)
BALB/cJ	MGP_BALBcJ_G0008371	miRNA gene	Chr18:62681799-62681864 (+)
C3H/HeJ	MGP_C3HHeJ_G0008316	miRNA gene	Chr18:64506399-64506464 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0008572	miRNA gene	Chr18:67132369-67132434 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0007605	miRNA gene	Chr18:61984379-61984444 (+)
CAST/EiJ	MGP_CASTEiJ_G0008178	miRNA gene	Chr18:64462704-64462769 (+)
CBA/J	MGP_CBAJ_G0008282	miRNA gene	Chr18:69303859-69303924 (+)
DBA/2J	MGP_DBA2J_G0008314	miRNA gene	Chr18:62196960-62197025 (+)
FVB/NJ	MGP_FVBNJ_G0008336	miRNA gene	Chr18:61588413-61588478 (+)
LP/J	MGP_LPJ_G0008399	miRNA gene	Chr18:65232472-65232537 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0008302	miRNA gene	Chr18:70759679-70759744 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0008561	miRNA gene	Chr18:64525370-64525435 (+)
PWK/PhJ	MGP_PWKPhJ_G0008100	miRNA gene	Chr18:62452467-62452532 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0007977	miRNA gene	Chr18:64664515-64664580 (+)
WSB/EiJ	MGP_WSBEiJ_G0008260	miRNA gene	Chr18:64376150-64376215 (+)

Human Ortholog

MIR122, microRNA 122

Vertebrate Orthologs

1

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MIR122, microRNA 122
Synonyms

hsa-mir-122, mir-122, MIR122A, MIRN122, MIRN122A, miRNA122, miRNA122A
Links

HGNC:31501

NCBI Gene ID: 406906
Chr Location

chr18:58451074-58451158 (+) GRCh38

MGI Vertebrate Homology

Mir122 stringent orthology
1 human;1 mouse
HCOP

vertebrate homology predictions: MIR122
Gene Tree

Mir122

Diseases

1 with human MIR122 associations

				Human Disease	Mouse Models
				hepatocellular carcinoma IDs hepatocellular carcinoma DOID:684 DOID:5005 EFO:0000182 ICD10CM:C22.0 MESH:D006528 NCI:C3099 OMIM:114550 ORDO:88673 UMLS_CUI:C2239176

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

31 phenotypes from 3 alleles in 3 genetic backgrounds
9 images
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

2
Targeted

5
Find Mice (IMSR)

9 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit steatohepatitis with fibrosis and hepatocellular carcinoma.

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All GO Annotations

8
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

739
Tissues

15
Literature Summary

14

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas

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All Sequences

26
RefSeq

1

Ensembl

ENSMUSG00000065402 (Evidence)
NCBI Gene

387231

Representative Sequences				Length	Strain/Species	Flank
	genomic	387231	NCBI Gene Model \| MGI Sequence Detail	66	C57BL/6J	± kb
	transcript	NR_029600	RefSeq \| MGI Sequence Detail	66	ZRU/MplStud

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All nucleic 6

Primer pair 2

Other 4

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miRBase

MI0000256

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MGI:2676806

Summaries

All 62

Developmental Gene Expression 14

Gene Ontology 6

Phenotypes 16
Earliest

J:84907 Lagos-Quintana M, et al., Identification of tissue-specific microRNAs from mouse. Curr Biol. 2002 Apr 30;12(9):735-9
Latest

J:345454 Xu L, et al., Limiting viral replication in hepatocytes alters Rift Valley fever virus disease manifestations. J Virol. 2023 Sep 28;97(9):e0085323

TSS for Mir122:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr151589	Chr18:65380187-65380198 (+)	-1,739 bp
Tssr151590	Chr18:65380253-65380265 (+)	-1,673 bp
Tssr151591	Chr18:65381309-65381331 (+)	-612 bp
Tssr151592	Chr18:65381995-65381996 (+)	64 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24