Mir124a-1 MGI Mouse Gene Detail - MGI:2676807

Symbol

Mir124a-1
Name

microRNA 124a-1
Synonyms

Mirn124a, Mirn124a-1, mmu-mir-124-1, mmu-mir-124a-1

Feature Type

miRNA gene
IDs

MGI:2676807
NCBI Gene: 387233
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr14:64828106-64828190 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 33.77 cM
Mapping Data

1 experiment

SNPs within 2kb

43 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2676807	miRNA gene	Chr14:64828106-64828190 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0008132	miRNA gene	Chr14:59153153-59153237 (+)
A/J	MGP_AJ_G0008119	miRNA gene	Chr14:57801539-57801623 (+)
AKR/J	MGP_AKRJ_G0008097	miRNA gene	Chr14:59828093-59828177 (+)
BALB/cJ	MGP_BALBcJ_G0008101	miRNA gene	Chr14:57749791-57749875 (+)
C3H/HeJ	MGP_C3HHeJ_G0008045	miRNA gene	Chr14:59462559-59462643 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0008291	miRNA gene	Chr14:61909059-61909143 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0007382	miRNA gene	Chr14:55740556-55740640 (+)
CAST/EiJ	MGP_CASTEiJ_G0007923	miRNA gene	Chr14:55943651-55943735 (+)
CBA/J	MGP_CBAJ_G0008013	miRNA gene	Chr14:63782351-63782435 (+)
DBA/2J	MGP_DBA2J_G0008049	miRNA gene	Chr14:57466041-57466125 (+)
FVB/NJ	MGP_FVBNJ_G0008072	miRNA gene	Chr14:56861892-56861976 (+)
LP/J	MGP_LPJ_G0008132	miRNA gene	Chr14:60188083-60188167 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0008041	miRNA gene	Chr14:62943510-62943594 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0008287	miRNA gene	Chr14:58993223-58993307 (+)
PWK/PhJ	MGP_PWKPhJ_G0007844	miRNA gene	Chr14:54151717-54151801 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0007740	miRNA gene	Chr14:54954143-54954227 (+)
WSB/EiJ	MGP_WSBEiJ_G0008000	miRNA gene	Chr14:59307175-59307259 (+)

Human Ortholog

MIR124-1, microRNA 124-1

Vertebrate Orthologs

1

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MIR124-1, microRNA 124-1
Synonyms

mir-124-1, MIR124A, MIR124A1, MIRN124-1, MIRN124A1
Links

HGNC:31502

NCBI Gene ID: 406907
Chr Location

chr8:9903388-9903472 (-) GRCh38

MGI Vertebrate Homology

Mir124a-1 stringent orthology
1 human;1 mouse
HCOP

vertebrate homology predictions: MIR124-1
Gene Tree

Mir124a-1

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Phenotype Summary

13 phenotypes from 2 alleles in 2 genetic backgrounds
2 phenotypes from multigenic genotypes
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Chemically induced (other)

1
Gene trapped

1
Targeted

1
Transgenic

1
Genomic Mutations

1 involving Mir124a-1
Find Mice (IMSR)

1 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a targeted mutation exhibit impaired hippocampal axogenesis and retinal cone cell survival.

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All GO Annotations

24
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

857
Tissues

80
Literature Summary

51

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas

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All Sequences

23
RefSeq

1

Ensembl

ENSMUSG00000065597 (Evidence)
NCBI Gene

387233

Representative Sequences				Length	Strain/Species	Flank
	genomic	387233	NCBI Gene Model \| MGI Sequence Detail	85	C57BL/6J	± kb
	transcript	NR_029813	RefSeq \| MGI Sequence Detail	85	C57BL/6

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All nucleic 20

Primer pair 8

Other 12

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miRBase

MI0000716

Summaries

All 81

Developmental Gene Expression 51

Gene Ontology 5

Phenotypes 7
Earliest

J:84907 Lagos-Quintana M, et al., Identification of tissue-specific microRNAs from mouse. Curr Biol. 2002 Apr 30;12(9):735-9
Latest

J:349888 Zhang J, et al., m(5)C methylated lncRncr3-MeCP2 interaction restricts miR124a-initiated neurogenesis. Nat Commun. 2024 Jun 15;15(1):5136

TSS for Mir124a-1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr126176	Chr14:64827138-64827202 (+)	-936 bp
Tssr126177	Chr14:64827251-64827297 (+)	-832 bp
Tssr126178	Chr14:64827310-64827347 (+)	-777 bp
Tssr126179	Chr14:64827349-64827359 (+)	-752 bp
Tssr126180	Chr14:64827743-64827756 (+)	-356 bp
Tssr126181	Chr14:64827827-64827838 (+)	-273 bp
Tssr126182	Chr14:64827853-64827875 (+)	-242 bp
Tssr126183	Chr14:64827887-64827901 (+)	-212 bp
Tssr126184	Chr14:64827910-64827922 (+)	-190 bp
Tssr126185	Chr14:64827930-64827937 (+)	-172 bp
Tssr126186	Chr14:64828178-64828181 (+)	74 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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