Mir133a-1 MGI Mouse Gene Detail - MGI:2676818

Symbol

Mir133a-1
Name

microRNA 133a-1
Synonyms

mir-133a-1, Mirn133, Mirn133a-1, mmu-mir-133a-1

Feature Type

miRNA gene
IDs

MGI:2676818
NCBI Gene: 387151
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr18:10782909-10782976 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 5.40 cM
Mapping Data

1 experiment

SNPs within 2kb

54 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2676818	miRNA gene	Chr18:10782909-10782976 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0008367	miRNA gene	Chr18:7725479-7725546 (-)
A/J	MGP_AJ_G0008356	miRNA gene	Chr18:7673372-7673439 (-)
AKR/J	MGP_AKRJ_G0008340	miRNA gene	Chr18:7875197-7875264 (-)
BALB/cJ	MGP_BALBcJ_G0008340	miRNA gene	Chr18:7657802-7657869 (-)
C3H/HeJ	MGP_C3HHeJ_G0008285	miRNA gene	Chr18:7768311-7768378 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0008539	miRNA gene	Chr18:8179854-8179921 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0007580	miRNA gene	Chr18:7350417-7350484 (-)
CAST/EiJ	MGP_CASTEiJ_G0008149	miRNA gene	Chr18:7664357-7664424 (-)
CBA/J	MGP_CBAJ_G0008252	miRNA gene	Chr18:8240849-8240916 (-)
DBA/2J	MGP_DBA2J_G0008283	miRNA gene	Chr18:7541215-7541282 (-)
FVB/NJ	MGP_FVBNJ_G0008307	miRNA gene	Chr18:7488878-7488945 (-)
LP/J	MGP_LPJ_G0008369	miRNA gene	Chr18:7852668-7852735 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0008271	miRNA gene	Chr18:8485465-8485532 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0008528	miRNA gene	Chr18:7704945-7705012 (-)
PWK/PhJ	MGP_PWKPhJ_G0008069	miRNA gene	Chr18:7574195-7574262 (-)
SPRET/EiJ	no annotation
WSB/EiJ	MGP_WSBEiJ_G0008230	miRNA gene	Chr18:7681174-7681241 (-)

Human Ortholog

MIR133A1, microRNA 133a-1

Vertebrate Orthologs

1

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MIR133A1, microRNA 133a-1
Synonyms

mir-133a-1, MIRN133A1
Links

HGNC:31517

NCBI Gene ID: 406922
Chr Location

chr18:21825698-21825785 (-) GRCh38

MGI Vertebrate Homology

Mir133a-1 stringent orthology
1 human;1 mouse
HCOP

vertebrate homology predictions: MIR133A1
Gene Tree

Mir133a-1

Diseases

1 with human MIR133A1 associations

				Human Disease	Mouse Models
				hepatocellular carcinoma IDs hepatocellular carcinoma DOID:684 DOID:5005 EFO:0000182 ICD10CM:C22.0 MESH:D006528 NCI:C3099 OMIM:114550 ORDO:88673 UMLS_CUI:C2239176

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype from 2 alleles in 2 genetic backgrounds
21 phenotypes from multigenic genotypes
13 phenotype references

All Mutations and Alleles

5
Targeted

4
Transgenic

1
Genomic Mutations

1 involving Mir133a-1
Find Mice (IMSR)

2 strains or lines available

Mice homozygous for a knock-out allele are viable with no apparent defects in behavior, weight, or life span.

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All GO Annotations

11
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

746
Tissues

10
Literature Summary

23

Images

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas

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All Sequences

23
RefSeq

1

Ensembl

ENSMUSG00000065399 (Evidence)
NCBI Gene

387151

Representative Sequences				Length	Strain/Species	Flank
	genomic	387151	NCBI Gene Model \| MGI Sequence Detail	68	C57BL/6J	± kb
	transcript	NR_029547	RefSeq \| MGI Sequence Detail	68	C57BL/6

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All nucleic 6

Primer pair 4

Other 2

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miRBase

MI0000159

Summaries

All 62

Developmental Gene Expression 23

Gene Ontology 6

Phenotypes 13
Earliest

J:84907 Lagos-Quintana M, et al., Identification of tissue-specific microRNAs from mouse. Curr Biol. 2002 Apr 30;12(9):735-9
Latest

J:328212 Klockner I, et al., Control of CRK-RAC1 activity by the miR-1/206/133 miRNA family is essential for neuromuscular junction function. Nat Commun. 2022 Jun 8;13(1):3180

TSS for Mir133a-1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr152436	Chr18:10782908-10782912 (-)	66 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24