Mir138-1 MGI Mouse Gene Detail - MGI:2676823

Symbol

Mir138-1
Name

microRNA 138-1
Synonyms

Mirn138, Mirn138-1, mmu-mir-138-1

Feature Type

miRNA gene
IDs

MGI:2676823
NCBI Gene: 387156
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr9:122511941-122512039 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 73.05 cM
Mapping Data

1 experiment

SNPs within 2kb

78 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2676823	miRNA gene	Chr9:122511941-122512039 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0009251	miRNA gene	Chr9:125680142-125680240 (+)
A/J	MGP_AJ_G0009231	miRNA gene	Chr9:120875680-120875778 (+)
AKR/J	MGP_AKRJ_G0009221	miRNA gene	Chr9:124128715-124128813 (+)
BALB/cJ	MGP_BALBcJ_G0009215	miRNA gene	Chr9:120798012-120798110 (+)
C3H/HeJ	MGP_C3HHeJ_G0009155	miRNA gene	Chr9:124559962-124560060 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0009458	miRNA gene	Chr9:129137600-129137698 (+)
CAROLI/EiJ	no annotation
CAST/EiJ	MGP_CASTEiJ_G0008986	miRNA gene	Chr9:124588379-124588477 (+)
CBA/J	MGP_CBAJ_G0009122	miRNA gene	Chr9:133861097-133861195 (+)
DBA/2J	MGP_DBA2J_G0009152	miRNA gene	Chr9:120323334-120323432 (+)
FVB/NJ	MGP_FVBNJ_G0009169	miRNA gene	Chr9:119244779-119244877 (+)
LP/J	MGP_LPJ_G0009249	miRNA gene	Chr9:126018675-126018773 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0009136	miRNA gene	Chr9:134726899-134726997 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0009428	miRNA gene	Chr9:124578552-124578650 (+)
PWK/PhJ	MGP_PWKPhJ_G0008911	miRNA gene	Chr9:120775678-120775776 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0008748	miRNA gene	Chr9:124655921-124656019 (+)
WSB/EiJ	MGP_WSBEiJ_G0009080	miRNA gene	Chr9:124424891-124424989 (+)

Human Ortholog

MIR138-1, microRNA 138-1

Vertebrate Orthologs

1

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MIR138-1, microRNA 138-1
Synonyms

mir-138-1, MIRN138-1
Links

HGNC:31524

NCBI Gene ID: 406929
Chr Location

chr3:44114212-44114310 (+) GRCh38

MGI Vertebrate Homology

Mir138-1 stringent orthology
1 human;1 mouse
HCOP

vertebrate homology predictions: MIR138-1
Gene Tree

Mir138-1

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
4 phenotype references

All Mutations and Alleles

3
Targeted

3
Find Mice (IMSR)

3 strains or lines available

Mice homozygous for a targeted deletion are viable with no observed pathologies.

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All GO Annotations

4
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

759
Tissues

13
Literature Summary

10

Images

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas

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All Sequences

23
RefSeq

1

Ensembl

ENSMUSG00000065414 (Evidence)
NCBI Gene

387156

Representative Sequences				Length	Strain/Species	Flank
	genomic	387156	NCBI Gene Model \| MGI Sequence Detail	99	C57BL/6J	± kb
	transcript	NR_029819	RefSeq \| MGI Sequence Detail	99	C57BL/6

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All nucleic 3

Primer pair 1

Other 2

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miRBase

MI0000722

Summaries

All 26

Developmental Gene Expression 10

Gene Ontology 4

Phenotypes 4
Earliest

J:84907 Lagos-Quintana M, et al., Identification of tissue-specific microRNAs from mouse. Curr Biol. 2002 Apr 30;12(9):735-9
Latest

J:318524 Bai XZ, et al., MicroRNA-138 Aggravates Inflammatory Responses of Macrophages by Targeting SIRT1 and Regulating the NF-kappaB and AKT Pathways. Cell Physiol Biochem. 2018;49(2):489-500

TSS for Mir138-1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr87849	Chr9:122510958-122510961 (+)	-981 bp
Tssr87850	Chr9:122511187-122511198 (+)	-748 bp
Tssr87851	Chr9:122511237-122511249 (+)	-698 bp
Tssr87852	Chr9:122512023-122512025 (+)	83 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24