Mir142 MGI Mouse Gene Detail - MGI:2676827

Symbol

Mir142
Name

microRNA 142
Synonyms

miR-142, Mirn142, mmu-mir-142

Feature Type

miRNA gene
IDs

MGI:2676827
NCBI Gene: 387160
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr11:87647690-87647753 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 52.21 cM
Mapping Data

1 experiment

SNPs within 2kb

31 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2676827	miRNA gene	Chr11:87647690-87647753 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0007859	miRNA gene	Chr11:89388879-89388942 (+)
A/J	MGP_AJ_G0007852	miRNA gene	Chr11:85942400-85942463 (+)
AKR/J	MGP_AKRJ_G0007827	miRNA gene	Chr11:88517099-88517162 (+)
BALB/cJ	MGP_BALBcJ_G0007831	miRNA gene	Chr11:86343560-86343623 (+)
C3H/HeJ	MGP_C3HHeJ_G0007777	miRNA gene	Chr11:88555694-88555757 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0008010	miRNA gene	Chr11:92104791-92104854 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0007151	miRNA gene	Chr11:82970364-82970427 (+)
CAST/EiJ	MGP_CASTEiJ_G0007671	miRNA gene	Chr11:89248868-89248931 (+)
CBA/J	MGP_CBAJ_G0007748	miRNA gene	Chr11:95970102-95970165 (+)
DBA/2J	MGP_DBA2J_G0007783	miRNA gene	Chr11:85496582-85496645 (+)
FVB/NJ	MGP_FVBNJ_G0007802	miRNA gene	Chr11:85002626-85002689 (+)
LP/J	MGP_LPJ_G0007861	miRNA gene	Chr11:89880556-89880619 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0007772	miRNA gene	Chr11:96013781-96013844 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0008006	miRNA gene	Chr11:88754484-88754547 (+)
PWK/PhJ	MGP_PWKPhJ_G0007598	miRNA gene	Chr11:86345766-86345829 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0007493	miRNA gene	Chr11:88312914-88312977 (+)
WSB/EiJ	MGP_WSBEiJ_G0007738	miRNA gene	Chr11:88645462-88645525 (+)

Human Ortholog

MIR142, microRNA 142

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MIR142, microRNA 142
Synonyms

mir-142, MIRN142
Links

HGNC:31529

NCBI Gene ID: 406934
Chr Location

chr17:58331232-58331318 (-) GRCh38

MGI Vertebrate Homology

Mir142 stringent orthology
1 human;1 mouse;2 zebrafish
HCOP

vertebrate homology predictions: MIR142
Gene Tree

Mir142

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Phenotype Summary

8 phenotypes from 2 alleles in 2 genetic backgrounds
22 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

1
Endonuclease-mediated

3
Targeted

10
Genomic Mutations

2 involving Mir142
Find Mice (IMSR)

4 strains or lines available

Mice homozygous for a knock-out allele exhibit reduced stimulated mast cell degranulation and impaired hematopoietic lineage formation.

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All GO Annotations

4
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

736
Tissues

12
Literature Summary

13

Images

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas

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All Sequences

25
RefSeq

1

Ensembl

ENSMUSG00000105196 (Evidence)
NCBI Gene

387160

Representative Sequences				Length	Strain/Species	Flank
	genomic	387160	NCBI Gene Model \| MGI Sequence Detail	64	C57BL/6J	± kb
	transcript	NR_029555	RefSeq \| MGI Sequence Detail	64	C57BL/6

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All nucleic 10

Primer pair 4

Other 6

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miRBase

MI0000167

Summaries

All 70

Developmental Gene Expression 13

Gene Ontology 4

Phenotypes 22
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:340297 Zhang B, et al., Acquired miR-142 deficit in leukemic stem cells suffices to drive chronic myeloid leukemia into blast crisis. Nat Commun. 2023 Sep 1;14(1):5325

TSS for Mir142:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr103969	Chr11:87647457-87647461 (+)	-231 bp
Tssr103970	Chr11:87647615-87647652 (+)	-56 bp
Tssr103971	Chr11:87647751-87647755 (+)	63 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24