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Mir143 Gene Detail
Summary
  • Symbol
    Mir143
  • Name
    microRNA 143
  • Synonyms
    Mirn143, mmu-mir-143
Location &
Maps
more
  • Sequence Map
    Chr18:61782267-61782329 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 34.64 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    106 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2676828
 miRNA gene Chr18:61782267-61782329 (-)
129S1/SvImJ MGP_129S1SvImJ_G0008396
 miRNA gene Chr18:61548750-61548812 (-)
A/J MGP_AJ_G0008385
 miRNA gene Chr18:58906275-58906337 (-)
AKR/J MGP_AKRJ_G0008369
 miRNA gene Chr18:60527964-60528026 (-)
BALB/cJ MGP_BALBcJ_G0008370
 miRNA gene Chr18:59030299-59030361 (-)
C3H/HeJ MGP_C3HHeJ_G0008315
 miRNA gene Chr18:60760977-60761039 (-)
C57BL/6NJ MGP_C57BL6NJ_G0008571
 miRNA gene Chr18:63220488-63220550 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0007604
 miRNA gene Chr18:58452011-58452073 (-)
CAST/EiJ MGP_CASTEiJ_G0008177
 miRNA gene Chr18:60642061-60642123 (-)
CBA/J MGP_CBAJ_G0008281
 miRNA gene Chr18:65268940-65269002 (-)
DBA/2J MGP_DBA2J_G0008313
 miRNA gene Chr18:58575624-58575686 (-)
FVB/NJ MGP_FVBNJ_G0008335
 miRNA gene Chr18:57981709-57981771 (-)
LP/J MGP_LPJ_G0008398
 miRNA gene Chr18:61406052-61406114 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0008301
 miRNA gene Chr18:66837179-66837241 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0008560
 miRNA gene Chr18:60734276-60734338 (-)
PWK/PhJ MGP_PWKPhJ_G0008099
 miRNA gene Chr18:58806295-58806357 (-)
SPRET/EiJ MGP_SPRETEiJ_G0007976
 miRNA gene Chr18:60962275-60962337 (-)
WSB/EiJ MGP_WSBEiJ_G0008259
 miRNA gene Chr18:60588273-60588335 (-)



Homology
more
  • Human Ortholog
    MIR143, microRNA 143
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MIR143, microRNA 143
  • Synonyms
    mir-143, MIRN143
  • Links
    NCBI Gene ID: 406935

  • Chr Location
    chr5:149428918-149429023 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit decreased blood pressure, reduced neointimal thickening and decreased medial thickness following carotid artery ligation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    741
  • Tissues
    18
  • Literature Summary
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      24
    • RefSeq
      1
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 387161 NCBI Gene Model | MGI Sequence Detail 63 C57BL/6J ±  kb
    transcript NR_029601 RefSeq | MGI Sequence Detail 63 C57BL/6  
    For the selected sequence
    Molecular
    Reagents
    less
    • All nucleic 7
      Primer pair 3
      Other 4
    Other Database
    Links
    less
    miRBase MI0000257
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 19
      Gene Ontology 8
      Phenotypes 11
    • Earliest
      J:84907 Lagos-Quintana M, et al., Identification of tissue-specific microRNAs from mouse. Curr Biol. 2002 Apr 30;12(9):735-9
    • Latest
      J:352144 Xiong JL, et al., Pituitary-derived small extracellular vesicles promote liver repair by its cargo miR-143-3p. Sci Rep. 2024 Jul 18;14(1):16635
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory