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Mir146 Gene Detail
Summary
  • Symbol
    Mir146
  • Name
    microRNA 146
  • Synonyms
    miR-146a, Mirn146, mmu-mir-146, mmu-mir-146a
  • Feature Type
    miRNA gene
  • IDs
    MGI:2676831
    NCBI Gene: 387164
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:43265224-43265288 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 25.68 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    136 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2676831
 miRNA gene Chr11:43265224-43265288 (-)
129S1/SvImJ MGP_129S1SvImJ_G0007796
 miRNA gene Chr11:42127279-42127343 (-)
A/J MGP_AJ_G0007792
 miRNA gene Chr11:40525837-40525901 (-)
AKR/J MGP_AKRJ_G0007766
 miRNA gene Chr11:41715902-41715966 (-)
BALB/cJ MGP_BALBcJ_G0007769
 miRNA gene Chr11:40696600-40696664 (-)
C3H/HeJ MGP_C3HHeJ_G0007716
 miRNA gene Chr11:41746373-41746437 (-)
C57BL/6NJ MGP_C57BL6NJ_G0007947
 miRNA gene Chr11:43421001-43421065 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0007093
 miRNA gene Chr11:38596841-38596905 (-)
CAST/EiJ MGP_CASTEiJ_G0007609
 miRNA gene Chr11:41797033-41797097 (-)
CBA/J MGP_CBAJ_G0007688
 miRNA gene Chr11:45417194-45417258 (-)
DBA/2J MGP_DBA2J_G0007722
 miRNA gene Chr11:40317068-40317132 (-)
FVB/NJ MGP_FVBNJ_G0007740
 miRNA gene Chr11:40002648-40002712 (-)
LP/J MGP_LPJ_G0007800
 miRNA gene Chr11:42376409-42376473 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0007710
 miRNA gene Chr11:47077455-47077519 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0007945
 miRNA gene Chr11:41866301-41866365 (-)
PWK/PhJ MGP_PWKPhJ_G0007539
 miRNA gene Chr11:40334373-40334437 (-)
SPRET/EiJ MGP_SPRETEiJ_G0007435
 miRNA gene Chr11:41662426-41662490 (-)
WSB/EiJ MGP_WSBEiJ_G0007677
 miRNA gene Chr11:41506783-41506847 (-)



Homology
more
  • Human Ortholog
    MIR146A, microRNA 146a
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MIR146A, microRNA 146a
  • Synonyms
    miR-146a, MIRN146, MIRN146A, miRNA146A
  • Links
    NCBI Gene ID: 406938

  • Chr Location
    chr5:160485352-160485450 (+)  GRCh38
Human Diseases
more
  • Diseases
    6 with human MIR146A associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    55 phenotypes from 4 alleles in 7 genetic backgrounds
    15 phenotypes from multigenic genotypes
    3 images
    73 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased sensitivity to LPS and develop a lympho- and myeloproliferative syndrome.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    711
  • Tissues
    5
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      24
    • RefSeq
      1
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 387164 NCBI Gene Model | MGI Sequence Detail 65 C57BL/6J ±  kb
    transcript NR_029558 RefSeq | MGI Sequence Detail 65 C57BL/6  
    For the selected sequence
    Molecular
    Reagents
    less
    • All nucleic 2
      Primer pair 1
      Other 1
    Other Database
    Links
    less
    miRBase MI0000170
    References
    more
    • Summaries
      All 141
      Developmental Gene Expression 7
      Gene Ontology 8
      Phenotypes 73
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:349370 Barreyro L, et al., Dysregulated innate immune signaling cooperates with RUNX1 mutations to transform an MDS-like disease to AML. iScience. 2024 Jun 21;27(6):109809
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory