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Mir18 Gene Detail
Summary
  • Symbol
    Mir18
  • Name
    microRNA 18
  • Synonyms
    Mirn18, mmu-mir-18, mmu-mir-18a
  • Feature Type
    miRNA gene
  • IDs
    MGI:2676844
    NCBI Gene: 387135
  • Member of
    Mirc1 cluster
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr14:115281283-115281378 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 59.40 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    83 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2676844
 miRNA gene Chr14:115281283-115281378 (+)
129S1/SvImJ MGP_129S1SvImJ_G0008152
 miRNA gene Chr14:112498158-112498253 (+)
A/J MGP_AJ_G0008140
 miRNA gene Chr14:108246715-108246810 (+)
AKR/J MGP_AKRJ_G0008119
 miRNA gene Chr14:111781845-111781940 (+)
BALB/cJ MGP_BALBcJ_G0008123
 miRNA gene Chr14:108763675-108763770 (+)
C3H/HeJ MGP_C3HHeJ_G0008066
 miRNA gene Chr14:111608036-111608131 (+)
C57BL/6NJ MGP_C57BL6NJ_G0008314
 miRNA gene Chr14:116827638-116827733 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0007397
 miRNA gene Chr14:104418047-104418142 (+)
CAST/EiJ MGP_CASTEiJ_G0007941
 miRNA gene Chr14:109385842-109385937 (+)
CBA/J MGP_CBAJ_G0008034
 miRNA gene Chr14:121366874-121366969 (+)
DBA/2J MGP_DBA2J_G0008070
 miRNA gene Chr14:108168318-108168413 (+)
FVB/NJ MGP_FVBNJ_G0008094
 miRNA gene Chr14:106513577-106513672 (+)
LP/J MGP_LPJ_G0008150
 miRNA gene Chr14:113525583-113525678 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0008061
 miRNA gene Chr14:126244633-126244728 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0008309
 miRNA gene Chr14:111207762-111207857 (+)
PWK/PhJ MGP_PWKPhJ_G0007863
 miRNA gene Chr14:105114298-105114393 (+)
SPRET/EiJ MGP_SPRETEiJ_G0007758
 miRNA gene Chr14:107345350-107345445 (+)
WSB/EiJ MGP_WSBEiJ_G0008019
 miRNA gene Chr14:111952086-111952181 (+)



Homology
more
  • Human Ortholog
    MIR18A, microRNA 18a
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MIR18A, microRNA 18a
  • Synonyms
    C13orf25, hsa-mir-18, hsa-mir-18a, MIR17HG, miR-18, MIR18, mir-18a, MIRH1, MIRHG1, MIRN18, MIRN18A, miRNA18A
  • Links
    NCBI Gene ID: 406953

  • Chr Location
    chr13:91350751-91350821 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    6 phenotype references
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    4 involving Mir18
  • Find Mice (IMSR)
    2 strains or lines available
Mice homozygous for a knock-out allele are viable and fertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    59
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    772
  • Tissues
    49
  • Literature Summary
    19
Sequences &
Gene Models
less
  • All Sequences
    24
  • RefSeq
    1
Representative SequencesLengthStrain/SpeciesFlank
genomic 387135 NCBI Gene Model | MGI Sequence Detail 96 C57BL/6J ±  kb
transcript NR_029736 RefSeq | MGI Sequence Detail 96 C57BL/6  
For the selected sequence
Molecular
Reagents
less
  • All nucleic 5
    Primer pair 4
    Other 1
Other Database
Links
less
miRBase MI0000567
References
more
  • Summaries
    All 47
    Developmental Gene Expression 19
    Gene Ontology 8
    Phenotypes 6
  • Earliest
    J:67314 Roix J, et al., Molecular and functional mapping of the piebald deletion complex on mouse chromosome 14. Genetics. 2001 Feb;157(2):803-15
  • Latest
    J:357455 Wang T, et al., miR-181c-5p suppresses neuronal pyroptosis via NLRP1 in Alzheimer's disease. Behav Brain Res. 2023 Jun 5;447:114387
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory