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Mir185 Gene Detail
Summary
  • Symbol
    Mir185
  • Name
    microRNA 185
  • Synonyms
    Mirn185, mmu-mir-185
  • Feature Type
    miRNA gene
  • IDs
    MGI:2676849
    NCBI Gene: 387180
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr16:18145265-18145329 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 11.35 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2676849
 miRNA gene Chr16:18145265-18145329 (-)
129S1/SvImJ MGP_129S1SvImJ_G0008254
 miRNA gene Chr16:15545475-15545539 (-)
A/J MGP_AJ_G0008243
 miRNA gene Chr16:14773370-14773434 (-)
AKR/J MGP_AKRJ_G0008226
 miRNA gene Chr16:15361542-15361606 (-)
BALB/cJ MGP_BALBcJ_G0008228
 miRNA gene Chr16:14921925-14921989 (-)
C3H/HeJ MGP_C3HHeJ_G0008170
 miRNA gene Chr16:15513454-15513518 (-)
C57BL/6NJ MGP_C57BL6NJ_G0008422
 miRNA gene Chr16:15819565-15819629 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0007490
 miRNA gene Chr16:14813626-14813690 (-)
CAST/EiJ MGP_CASTEiJ_G0008041
 miRNA gene Chr16:15406824-15406888 (-)
CBA/J MGP_CBAJ_G0008139
 miRNA gene Chr16:16516878-16516942 (-)
DBA/2J MGP_DBA2J_G0008172
 miRNA gene Chr16:14691610-14691674 (-)
FVB/NJ MGP_FVBNJ_G0008197
 miRNA gene Chr16:14743293-14743357 (-)
LP/J MGP_LPJ_G0008254
 miRNA gene Chr16:15321342-15321406 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0008160
 miRNA gene Chr16:16153031-16153095 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0008413
 miRNA gene Chr16:15290920-15290984 (-)
PWK/PhJ MGP_PWKPhJ_G0007963
 miRNA gene Chr16:14963532-14963596 (-)
SPRET/EiJ MGP_SPRETEiJ_G0007854
 miRNA gene Chr16:15259744-15259808 (-)
WSB/EiJ MGP_WSBEiJ_G0008118
 miRNA gene Chr16:15288010-15288074 (-)



Homology
more
  • Human Ortholog
    MIR185, microRNA 185
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MIR185, microRNA 185
  • Synonyms
    miR-185, MIRN185
  • Links
    NCBI Gene ID: 406961

  • Chr Location
    chr22:20033139-20033220 (+)  GRCh38
Human Diseases
less
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    129 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele do not exhibit spontaneous phenotypes. Ovariectomized females show decreased osteoporosis development and primary osteoblasts and mesenchymal stem cells show enhanced osteogenesis in culture.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    2
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    727
  • Tissues
    18
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      24
    • RefSeq
      1
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 387180 NCBI Gene Model | MGI Sequence Detail 65 C57BL/6J ±  kb
    transcript NR_029571 RefSeq | MGI Sequence Detail 65 C57BL/6  
    For the selected sequence
    Molecular
    Reagents
    less
    • All nucleic 4
      Primer pair 3
      Other 1
    Other Database
    Links
    less
    miRBase MI0000227
    References
    more
    • Summaries
      All 144
      Developmental Gene Expression 6
      Diseases 5
      Gene Ontology 2
      Phenotypes 129
    • Earliest
      J:57757 Lindsay EA, et al., Congenital heart disease in mice deficient for the DiGeorge syndrome region [see comments]. Nature. 1999 Sep 23;401(6751):379-83
    • Latest
      J:351616 Pechous RD, et al., SARS-CoV-2 Infection Causes Heightened Disease Severity and Mortality in a Mouse Model of Down Syndrome. Biomedicines. 2024 Feb 28;12(3)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory