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Mir188 Gene Detail
Summary
  • Symbol
    Mir188
  • Name
    microRNA 188
  • Synonyms
    Mirn188, mmu-mir-188
  • Feature Type
    miRNA gene
  • IDs
    MGI:2676852
    NCBI Gene: 387183
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    ChrX:7114228-7114295 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 3.25 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    84 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2676852
 miRNA gene ChrX:7114228-7114295 (-)
129S1/SvImJ MGP_129S1SvImJ_G0009256
 miRNA gene ChrX:1837500-1837567 (-)
A/J MGP_AJ_G0009236
 miRNA gene ChrX:1810469-1810536 (-)
AKR/J MGP_AKRJ_G0009226
 miRNA gene ChrX:1894520-1894587 (-)
BALB/cJ MGP_BALBcJ_G0009220
 miRNA gene ChrX:1837820-1837887 (-)
C3H/HeJ MGP_C3HHeJ_G0009160
 miRNA gene ChrX:1882309-1882376 (-)
C57BL/6NJ MGP_C57BL6NJ_G0009463
 miRNA gene ChrX:1913167-1913234 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0008311
 miRNA gene ChrX:1385012-1385079 (-)
CAST/EiJ MGP_CASTEiJ_G0008990
 miRNA gene ChrX:1771535-1771602 (-)
CBA/J MGP_CBAJ_G0009127
 miRNA gene ChrX:2017181-2017248 (-)
DBA/2J MGP_DBA2J_G0009157
 miRNA gene ChrX:1842631-1842698 (-)
FVB/NJ MGP_FVBNJ_G0009174
 miRNA gene ChrX:1802760-1802827 (-)
LP/J MGP_LPJ_G0009254
 miRNA gene ChrX:1844350-1844417 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0009141
 miRNA gene ChrX:1980496-1980563 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0009433
 miRNA gene ChrX:1832289-1832356 (-)
PWK/PhJ MGP_PWKPhJ_G0008916
 miRNA gene ChrX:1764679-1764746 (-)
SPRET/EiJ MGP_SPRETEiJ_G0008753
 miRNA gene ChrX:1788235-1788302 (-)
WSB/EiJ MGP_WSBEiJ_G0009085
 miRNA gene ChrX:1838906-1838973 (-)



Homology
more
  • Human Ortholog
    MIR188, microRNA 188
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MIR188, microRNA 188
  • Synonyms
    miR-188, MIRN188
  • Links
    NCBI Gene ID: 406964

  • Chr Location
    chrX:50003503-50003588 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 3 alleles in 3 genetic backgrounds
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one targeted deletion are viable with no observed pathologies. Mice homozygous for a different allele exhibit increased bone formation and ossification swith increased osteoblasts and reduced adipocyte differentiation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    740
  • Tissues
    6
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      24
    • RefSeq
      1
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 387183 NCBI Gene Model | MGI Sequence Detail 68 C57BL/6J ±  kb
    transcript NR_029574 RefSeq | MGI Sequence Detail 68 C57BL/6  
    For the selected sequence
    Molecular
    Reagents
    less
    • All nucleic 2
      Other 2
    Other Database
    Links
    less
    miRBase MI0000230
    References
    more
    • Summaries
      All 15
      Developmental Gene Expression 2
      Gene Ontology 1
      Phenotypes 4
    • Earliest
      J:84908 Lagos-Quintana M, et al., New microRNAs from mouse and human. RNA. 2003 Feb;9(2):175-9
    • Latest
      J:338874 He WZ, et al., miR-188-3p targets skeletal endothelium coupling of angiogenesis and osteogenesis during ageing. Cell Death Dis. 2022 May 25;13(5):494
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory