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Mir21a Gene Detail
Summary
  • Symbol
    Mir21a
  • Name
    microRNA 21a
  • Synonyms
    Mirn21, mmu-mir-21, mmu-mir-21a
  • Feature Type
    miRNA gene
  • IDs
    MGI:2676885
    NCBI Gene: 387140
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:86474893-86474984 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 51.82 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    61 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2676885
 miRNA gene Chr11:86474893-86474984 (-)
129S1/SvImJ MGP_129S1SvImJ_G0007856
 miRNA gene Chr11:88153207-88153298 (-)
A/J MGP_AJ_G0007849
 miRNA gene Chr11:84762070-84762161 (-)
AKR/J MGP_AKRJ_G0007824
 miRNA gene Chr11:87298180-87298271 (-)
BALB/cJ MGP_BALBcJ_G0007828
 miRNA gene Chr11:85145486-85145577 (-)
C3H/HeJ MGP_C3HHeJ_G0007774
 miRNA gene Chr11:87322272-87322363 (-)
C57BL/6NJ MGP_C57BL6NJ_G0008007
 miRNA gene Chr11:90814776-90814867 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0007148
 miRNA gene Chr11:81784637-81784728 (-)
CAST/EiJ MGP_CASTEiJ_G0007668
 miRNA gene Chr11:88010550-88010641 (-)
CBA/J MGP_CBAJ_G0007745
 miRNA gene Chr11:94638947-94639038 (-)
DBA/2J MGP_DBA2J_G0007780
 miRNA gene Chr11:84330642-84330733 (-)
FVB/NJ MGP_FVBNJ_G0007799
 miRNA gene Chr11:83833364-83833455 (-)
LP/J MGP_LPJ_G0007858
 miRNA gene Chr11:88639692-88639783 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0007769
 miRNA gene Chr11:94736728-94736819 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0008003
 miRNA gene Chr11:87542656-87542747 (-)
PWK/PhJ MGP_PWKPhJ_G0007595
 miRNA gene Chr11:85125260-85125351 (-)
SPRET/EiJ MGP_SPRETEiJ_G0007490
 miRNA gene Chr11:87095791-87095882 (-)
WSB/EiJ MGP_WSBEiJ_G0007735
 miRNA gene Chr11:87413381-87413472 (-)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    49 phenotypes from 9 alleles in 10 genetic backgrounds
    21 phenotypes from multigenic genotypes
    2 images
    96 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit normal cardiac morphology and response to stress, with the exception of a mildly exaggerated increase in heart weight in Ang II-treated mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    709
  • Tissues
    3
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      24
    • RefSeq
      1
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 387140 NCBI Gene Model | MGI Sequence Detail 92 C57BL/6J ±  kb
    transcript NR_029738 RefSeq | MGI Sequence Detail 92 C57BL/6  
    For the selected sequence
    Molecular
    Reagents
    less
    • All nucleic 3
      Primer pair 1
      Other 2
    Other Database
    Links
    less
    miRBase MI0000569
    References
    more
    • Summaries
      All 208
      Developmental Gene Expression 14
      Gene Ontology 12
      Phenotypes 96
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:344228 Xu C, et al., Hepatocyte miR-21-5p-deficiency Alleviates APAP-Induced Liver injury by inducing PPARgamma and Autophagy. Toxicol Sci. 2024 Jan 5;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory