Mir214 MGI Mouse Gene Detail - MGI:2676890

Symbol

Mir214
Name

microRNA 214
Synonyms

Mirn214, miRNA019, mmu-mir-214

Feature Type

miRNA gene
IDs

MGI:2676890
NCBI Gene: 387210
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr1:162050937-162051046 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 70.07 cM
Mapping Data

1 experiment

SNPs within 2kb

83 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2676890	miRNA gene	Chr1:162050937-162051046 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0007674	miRNA gene	Chr1:167548698-167548807 (+)
A/J	MGP_AJ_G0007668	miRNA gene	Chr1:160728567-160728676 (+)
AKR/J	MGP_AKRJ_G0007642	miRNA gene	Chr1:165602754-165602863 (+)
BALB/cJ	MGP_BALBcJ_G0007646	miRNA gene	Chr1:161263056-161263165 (+)
C3H/HeJ	MGP_C3HHeJ_G0007590	miRNA gene	Chr1:165820582-165820691 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0007820	miRNA gene	Chr1:173193852-173193961 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0006984	miRNA gene	Chr1:152803116-152803222 (+)
CAST/EiJ	MGP_CASTEiJ_G0007488	miRNA gene	Chr1:165454006-165454115 (+)
CBA/J	MGP_CBAJ_G0007565	miRNA gene	Chr1:179362748-179362857 (+)
DBA/2J	MGP_DBA2J_G0007599	miRNA gene	Chr1:159680160-159680269 (+)
FVB/NJ	MGP_FVBNJ_G0007615	miRNA gene	Chr1:158098508-158098617 (+)
LP/J	MGP_LPJ_G0007679	miRNA gene	Chr1:168660853-168660962 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0007589	miRNA gene	Chr1:186882123-186882232 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0007821	miRNA gene	Chr1:165435818-165435927 (+)
PWK/PhJ	MGP_PWKPhJ_G0007421	miRNA gene	Chr1:158853207-158853316 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0007323	miRNA gene	Chr1:164315633-164315742 (+)
WSB/EiJ	MGP_WSBEiJ_G0007556	miRNA gene	Chr1:165614758-165614867 (+)

Human Ortholog

MIR214, microRNA 214

Vertebrate Orthologs

1

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MIR214, microRNA 214
Synonyms

mir-214, MIRN214, miRNA214
Links

HGNC:31591

NCBI Gene ID: 406996
Chr Location

chr1:172138798-172138907 (-) GRCh38

MGI Vertebrate Homology

Mir214 stringent orthology
1 human;1 mouse
HCOP

vertebrate homology predictions: MIR214
Gene Tree

Mir214

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

2
Targeted

2
Transgenic

1
Genomic Mutations

2 involving Mir214
Find Mice (IMSR)

1 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit increased myocyte apoptosis, fibrosis and myocyte size following cardiac ischemia and reperfusion with altered calcium transients in cardiomyocytes.

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All GO Annotations

18
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

759
Tissues

36
Literature Summary

15

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas

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All Sequences

24
RefSeq

1

Ensembl

ENSMUSG00000065516 (Evidence)
NCBI Gene

387210

Representative Sequences				Length	Strain/Species	Flank
	genomic	387210	NCBI Gene Model \| MGI Sequence Detail	110	C57BL/6J	± kb
	transcript	NR_029796	RefSeq \| MGI Sequence Detail	110	C57BL/6

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All nucleic 11

Primer pair 4

Other 7

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miRBase

MI0000698

Summaries

All 56

Developmental Gene Expression 15

Gene Ontology 7

Phenotypes 10
Earliest

J:84906 Dostie J, et al., Numerous microRNPs in neuronal cells containing novel microRNAs. (Erratum: RNA 2003;9(5):631-2). RNA. 2003 Feb;9(2):180-6
Latest

J:355495 Li Y, et al., Vascular smooth muscle cell-specific miRNA-214 deficiency alleviates simulated microgravity-induced vascular remodeling. FASEB J. 2024 Jan;38(1):e23369

TSS for Mir214:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr9714	Chr1:162051028-162051030 (+)	92 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24