Mir22 MGI Mouse Gene Detail - MGI:2676896

Symbol

Mir22
Name

microRNA 22
Synonyms

Mirn22, mmu-mir-22

Feature Type

miRNA gene
IDs

MGI:2676896
NCBI Gene: 387141
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr11:75354542-75354636 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 45.91 cM
Mapping Data

1 experiment

SNPs within 2kb

58 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2676896	miRNA gene	Chr11:75354542-75354636 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0007842	miRNA gene	Chr11:76210792-76210886 (+)
A/J	MGP_AJ_G0007837	miRNA gene	Chr11:73379171-73379265 (+)
AKR/J	MGP_AKRJ_G0007812	miRNA gene	Chr11:75598981-75599075 (+)
BALB/cJ	MGP_BALBcJ_G0007815	miRNA gene	Chr11:73750371-73750465 (+)
C3H/HeJ	MGP_C3HHeJ_G0007762	miRNA gene	Chr11:75615843-75615937 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0007993	miRNA gene	Chr11:78596318-78596412 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0007137	miRNA gene	Chr11:70389106-70389200 (+)
CAST/EiJ	MGP_CASTEiJ_G0007655	miRNA gene	Chr11:76008782-76008876 (+)
CBA/J	MGP_CBAJ_G0007733	miRNA gene	Chr11:82048620-82048714 (+)
DBA/2J	MGP_DBA2J_G0007768	miRNA gene	Chr11:72983952-72984046 (+)
FVB/NJ	MGP_FVBNJ_G0007786	miRNA gene	Chr11:72543699-72543793 (+)
LP/J	MGP_LPJ_G0007846	miRNA gene	Chr11:76800359-76800453 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0007756	miRNA gene	Chr11:82614443-82614537 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0007990	miRNA gene	Chr11:75808176-75808270 (+)
PWK/PhJ	MGP_PWKPhJ_G0007583	miRNA gene	Chr11:73679645-73679739 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0007478	miRNA gene	Chr11:75361233-75361327 (+)
WSB/EiJ	MGP_WSBEiJ_G0007723	miRNA gene	Chr11:75615404-75615498 (+)

Human Ortholog

MIR22, microRNA 22

Vertebrate Orthologs

1

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MIR22, microRNA 22
Synonyms

hsa-mir-22, miR-22, MIRN22
Links

HGNC:31599

NCBI Gene ID: 407004
Chr Location

chr17:1713903-1713987 (-) GRCh38

MGI Vertebrate Homology

Mir22 stringent orthology
1 human;1 mouse
HCOP

vertebrate homology predictions: MIR22
Gene Tree

Mir22

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Phenotype Summary

27 phenotypes from 4 alleles in 4 genetic backgrounds
7 phenotypes from multigenic genotypes
30 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

1
Endonuclease-mediated

5
Targeted

8
Genomic Mutations

2 involving Mir22
Find Mice (IMSR)

6 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit impaired cardiac function following treatment with dobutamine or transverse aortic constriction. Another homozygous knock-out allele shows altered cardiac responses to isoproterenol-induced stress.

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All GO Annotations

5
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

720
Tissues

6
Literature Summary

3

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas

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All Sequences

23
RefSeq

1

Ensembl

ENSMUSG00000065529 (Evidence)
NCBI Gene

387141

Representative Sequences				Length	Strain/Species	Flank
	genomic	387141	NCBI Gene Model \| MGI Sequence Detail	95	C57BL/6J	± kb
	transcript	NR_029739	RefSeq \| MGI Sequence Detail	95	C57BL/6

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All nucleic 2

Primer pair 1

Other 1

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miRBase

MI0000570

Summaries

All 59

Developmental Gene Expression 3

Gene Ontology 5

Phenotypes 30
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345720 de Sousa E, et al., Sex-specific regulation of miR-22 and ERalpha in white adipose tissue of obese dam's female offspring impairs the early postnatal development of functional beige adipocytes in mice. Biochim Biophys Acta Mol Basis Dis. 2024 Feb 7;1870(4):167057

TSS for Mir22:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr102946	Chr11:75354497-75354509 (+)	-39 bp
Tssr102947	Chr11:75354619-75354623 (+)	79 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24