Dagla MGI Mouse Gene Detail - MGI:2677061 - diacylglycerol lipase, alpha

Symbol

Dagla
Name

diacylglycerol lipase, alpha
Synonyms

Nsddr

Feature Type

protein coding gene
IDs

MGI:2677061
NCBI Gene: 269060
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr19:10222629-10282241 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 6.55 cM
Mapping Data

1 experiment

SNPs within 2kb

1258 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2677061	protein coding gene	Chr19:10222629-10282323 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024842	protein coding gene	Chr19:7569979-7632892 (-)
A/J	MGP_AJ_G0024810	protein coding gene	Chr19:7052005-7111651 (-)
AKR/J	MGP_AKRJ_G0024785	protein coding gene	Chr19:7332357-7394002 (-)
BALB/cJ	MGP_BALBcJ_G0024810	protein coding gene	Chr19:7098791-7158211 (-)
C3H/HeJ	MGP_C3HHeJ_G0024576	protein coding gene	Chr19:7220001-7282123 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025258	protein coding gene	Chr19:7923489-7984744 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022685	protein coding gene	Chr19:7470097-7530382 (-)
CAST/EiJ	MGP_CASTEiJ_G0024049	protein coding gene	Chr19:6879687-6940600 (-)
CBA/J	MGP_CBAJ_G0024550	protein coding gene	Chr19:7964867-8026723 (-)
DBA/2J	MGP_DBA2J_G0024677	protein coding gene	Chr19:7065722-7124906 (-)
FVB/NJ	MGP_FVBNJ_G0024644	protein coding gene	Chr19:7104136-7163298 (-)
LP/J	MGP_LPJ_G0024764	protein coding gene	Chr19:7545179-7605345 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024671	protein coding gene	Chr19:7870960-7929670 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025306	protein coding gene	Chr19:7356145-7416047 (-)
PWK/PhJ	MGP_PWKPhJ_G0023794	protein coding gene	Chr19:6506347-6565727 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023599	protein coding gene	Chr19:6540289-6600565 (-)
WSB/EiJ	MGP_WSBEiJ_G0024111	protein coding gene	Chr19:7239563-7298272 (-)

Human Ortholog

DAGLA, diacylglycerol lipase alpha

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DAGLA, diacylglycerol lipase alpha
Synonyms

C11orf11, DAGL(ALPHA), DAGLALPHA, NOC2, NSDDR
Links

HGNC:1165

NCBI Gene ID: 747

neXtProt AC: NX_Q9Y4D2

UniProt: Q9Y4D2
Chr Location

11q12.2; chr11:61680391-61747001 (+) GRCh38

MGI Vertebrate Homology

Dagla stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DAGLA
Gene Tree

Dagla

Diseases

1 with human DAGLA associations

				Human Disease	Mouse Models
				lung cancer IDs lung cancer DOID:1324 DOID:13075 DOID:1322 DOID:9881 ICD10CM:C34.1 ICD10CM:C34.2 ICD10CM:C34.3 ICD9CM:162.3 ICD9CM:162.4 ICD9CM:162.5 ICD9CM:162.8 OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210 UMLS_CUI:C0024624 UMLS_CUI:C0153491 UMLS_CUI:C0153492 UMLS_CUI:C0153493

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

21 phenotypes from 4 alleles in 5 genetic backgrounds
1 phenotype from multigenic genotypes
39 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

20
Endonuclease-mediated

2
Gene trapped

7
Targeted

11
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

62 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for null mutations have decreased body weight, adult neuronal proliferation, and nervous system endocannaboid levels and abnormal inhibitory postsynaptic currents.

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All GO Annotations

34
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

735
Tissues

9
cDNA Data

37
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dagla

ZFIN dagla

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All Sequences

45
RefSeq

6
UniProt

3
CCDS

CCDS29574.1

Ensembl

ENSMUSG00000035735 (Evidence)
NCBI Gene

269060

			Length	Strain/Species	Flank
genomic	ENSMUSG00000035735	Ensembl Gene Model \| MGI Sequence Detail	59613	C57BL/6J	± kb
transcript	ENSMUST00000039327	Ensembl \| MGI Sequence Detail	5634	Not Applicable
polypeptide	ENSMUSP00000046358	Ensembl \| MGI Sequence Detail	1044	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000006268 diacylglycerol lipase-alpha

(term hierarchy)
EC

3.1.1.116
InterPro Domains

IPR029058 Alpha/Beta hydrolase fold

IPR052214 Diacylglycerol Lipase-Related

IPR002921 Fungal lipase-like domain
GlyGen

Q6WQJ1 2 sites, 1 O-linked glycan (1 site)

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All nucleic 37

cDNA 37

Microarray probesets 3

Summaries

All 78

Developmental Gene Expression 9

Gene Ontology 12

Phenotypes 39
Earliest

J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Dagla:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr158178	Chr19:10282231-10282318 (-)	-34 bp
Tssr158177	Chr19:10282218-10282229 (-)	17 bp
Tssr158176	Chr19:10250294-10250297 (-)	31,945 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24