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Rnf133 Gene Detail
Summary
  • Symbol
    Rnf133
  • Name
    ring finger protein 133
  • Synonyms
    Greul2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2677436
    NCBI Gene: 386611
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:23648868-23650304 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 11.01 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    129 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2677436
 protein coding gene Chr6:23648868-23650304 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030489
 protein coding gene Chr6:21198203-21199639 (-)
A/J MGP_AJ_G0030462
 protein coding gene Chr6:20299730-20301166 (-)
AKR/J MGP_AKRJ_G0030389
 protein coding gene Chr6:20961726-20963162 (-)
BALB/cJ MGP_BALBcJ_G0030472
 protein coding gene Chr6:20401544-20402980 (-)
C3H/HeJ MGP_C3HHeJ_G0030185
 protein coding gene Chr6:20957453-20958889 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030926
 protein coding gene Chr6:21859000-21860436 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028137
 protein coding gene Chr6:18841104-18842540 (-)
CAST/EiJ MGP_CASTEiJ_G0029587
 protein coding gene Chr6:20836855-20838291 (-)
CBA/J MGP_CBAJ_G0030163
 protein coding gene Chr6:22614789-22616225 (-)
DBA/2J MGP_DBA2J_G0030307
 protein coding gene Chr6:20262876-20264312 (-)
FVB/NJ MGP_FVBNJ_G0030261
 protein coding gene Chr6:20026599-20028035 (-)
LP/J MGP_LPJ_G0030394
 protein coding gene Chr6:21337463-21338899 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030297
 protein coding gene Chr6:24486757-24488193 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030956
 protein coding gene Chr6:20921223-20922659 (-)
PWK/PhJ MGP_PWKPhJ_G0029301
 protein coding gene Chr6:19859908-19861344 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029137
 protein coding gene Chr6:20636248-20637684 (-)
WSB/EiJ MGP_WSBEiJ_G0029663
 protein coding gene Chr6:20838343-20839779 (-)



Homology
more
  • Human Ortholog
    RNF133, ring finger protein 133
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RNF133, ring finger protein 133
  • Links
    NCBI Gene ID: 168433
    neXtProt AC: NX_Q8WVZ7
    UniProt: Q8WVZ7

  • Chr Location
    7q31.32; chr7:122697735-122699117 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    7 phenotypes from multigenic genotypes
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null males show severely reduced fertility, with abnormal sperm morphology and motility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    722
  • Tissues
    16
  • cDNA Data
    6
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 386611 NCBI Gene Model | MGI Sequence Detail 1437 C57BL/6J ±  kb
    transcript NM_198251 RefSeq | MGI Sequence Detail 1308 C57BL/6  
    polypeptide Q14B02 UniProt | EBI | MGI Sequence Detail 382 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 6

      Microarray probesets 3
    References
    more
    • Summaries
      All 25
      Developmental Gene Expression 1
      Gene Ontology 3
      Phenotypes 4
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory