U2af1l4 MGI Mouse Gene Detail - MGI:2678374 - U2 small nuclear RNA auxiliary factor 1-like 4

Symbol

U2af1l4
Name

U2 small nuclear RNA auxiliary factor 1-like 4
Synonyms

auxiliary factor 26, U2af26

Feature Type

protein coding gene
IDs

MGI:2678374
NCBI Gene: 233073
Alliance

genome feature page
Transcription Start Sites

1 TSS

Sequence Map

Chr7:30262765-30264789 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 18.61 cM
Mapping Data

1 experiment

SNPs within 2kb

130 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2678374	protein coding gene	Chr7:30262726-30264790 (+)
129S1/SvImJ	ENSMUSG00200023091	protein coding gene	Chr7:20042984-20045030 (+)
A/J	ENSMUSG00195044123	protein coding gene	Chr7:22711815-22713861 (+)
AKR/J	ENSMUSG00220045323	protein coding gene	Chr7:21767400-21769446 (-)
BALB/cJ	ENSMUSG00180015532	protein coding gene	Chr7:20771292-20773338 (+)
C3H/HeJ	ENSMUSG00175029228	protein coding gene	Chr7:21851775-21853821 (+)
C57BL/6NJ	ENSMUSG00215052213	protein coding gene	Chr7:19953903-19955949 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029529	protein coding gene	Chr7:29795822-29800521 (+)
CAST/EiJ	ENSTCUG00005040843	protein coding gene	Chr7:21752593-21754639 (+)
CBA/J	ENSMUSG00210025149	protein coding gene	Chr7:21014383-21016429 (+)
DBA/2J	ENSMUSG00185046502	protein coding gene	Chr7:24102576-24104622 (+)
FVB/NJ	ENSMUSG00205010633	protein coding gene	Chr7:20763400-20765446 (+)
JF1/MsJ	ENSUMUG00000055388	protein coding gene	Chr7:28548129-28550191 (+)
LP/J	ENSMUSG00230052060	protein coding gene	Chr7:29273026-29275072 (+)
NOD/ShiLtJ	ENSMUSG00190007758	protein coding gene	Chr7:20436234-20438280 (+)
NZO/HlLtJ	ENSMUSG00225026172	protein coding gene	Chr7:28113427-28115489 (+)
PWK/PhJ	no annotation
SPRET/EiJ	ENSMSPG00010032902	protein coding gene	Chr7:19841114-19843175 (+)
WSB/EiJ	ENSIUOG00005047631	protein coding gene	Chr7:14724762-14726808 (+)

Human Ortholog

U2AF1L4, U2 small nuclear RNA auxiliary factor 1 like 4

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

U2AF1L4, U2 small nuclear RNA auxiliary factor 1 like 4
Synonyms

U2AF1L3, U2AF1L3V1, U2AF1-RS3, U2AF1RS3, U2af26
Links

HGNC:23020

NCBI Gene ID: 199746

UniProt: Q8WU68
Chr Location

19q13.12; chr19:35742464-35745445 (-) GRCh38

MGI Vertebrate Homology

U2af1l4 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: U2AF1L4
Gene Tree

U2af1l4

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
3 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Targeted

4
Find Mice (IMSR)

9 strains or lines available

Mice homozygous for a null allele display abnormal circadian rhythms in response to changing external cues.

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All GO Annotations

19
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

13
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

109
RefSeq

2
UniProt

16
CCDS

CCDS21100.1

Ensembl

ENSMUSG00000078765 (Evidence)
NCBI Gene

233073

			Length	Strain/Species	Flank
genomic	233073	NCBI Gene Model \| MGI Sequence Detail	2025	C57BL/6J	± kb
transcript	NM_170760	RefSeq \| MGI Sequence Detail	864	C57BL/6
polypeptide	Q8BGJ9	UniProt \| EBI \| MGI Sequence Detail	220	Not Applicable

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UniProt

16 Sequences
Protein Ontology

PR:000016945 splicing factor U2AF 26 kDa subunit

(term hierarchy)

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All nucleic 15

cDNA 15

Microarray probesets 4

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MGI:2141802, MGI:2141967, MGI:2142260

Summaries

All 34

Developmental Gene Expression 1

Gene Ontology 7

Phenotypes 3
Earliest

J:83847 Shepard J, et al., Characterization of U2AF(6), a splicing factor related to U2AF(35). Mol Cell Biol. 2002 Jan;22(1):221-30
Latest

J:380397 Goldbraikh D, et al., USP1 deubiquitinates Akt to inhibit PI3K-Akt-FoxO signaling in muscle during prolonged starvation. EMBO Rep. 2020 Apr 3;21(4):e48791

TSS for U2af1l4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr65788	Chr7:30262723-30262774 (+)	-16 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24