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Sh3tc1 Gene Detail
Summary
  • Symbol
    Sh3tc1
  • Name
    SH3 domain and tetratricopeptide repeats 1
  • Synonyms
    MGC:67153
  • Feature Type
    protein coding gene
  • IDs
    MGI:2678949
    NCBI Gene: 231147
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:35854524-35897331 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 18.60 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1348 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2678949
 protein coding gene Chr5:35854524-35897331 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029483
 protein coding gene Chr5:33997586-34040284 (-)
A/J MGP_AJ_G0029450
 protein coding gene Chr5:32884402-32927989 (-)
AKR/J MGP_AKRJ_G0029399
 protein coding gene Chr5:34146588-34189393 (-)
BALB/cJ MGP_BALBcJ_G0029460
 protein coding gene Chr5:33397804-33440633 (-)
C3H/HeJ MGP_C3HHeJ_G0029182
 protein coding gene Chr5:34155188-34199045 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029914
 protein coding gene Chr5:35905670-35937394 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027151
 protein coding gene Chr5:30641179-30685607 (-)
CAST/EiJ MGP_CASTEiJ_G0028591
 protein coding gene Chr5:33254929-33297891 (-)
CBA/J MGP_CBAJ_G0029150
 protein coding gene Chr5:36750020-36792716 (-)
DBA/2J MGP_DBA2J_G0029298
 protein coding gene Chr5:33029341-33072848 (-)
FVB/NJ MGP_FVBNJ_G0029257
 protein coding gene Chr5:32495454-32540754 (-)
LP/J MGP_LPJ_G0029383
 protein coding gene Chr5:34421234-34464077 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029287
 protein coding gene Chr5:37538355-37581870 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029947
 protein coding gene Chr5:33641427-33685013 (-)
PWK/PhJ MGP_PWKPhJ_G0028316
 protein coding gene Chr5:32195035-32236685 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028147
 protein coding gene Chr5:33109574-33171083 (-)
WSB/EiJ MGP_WSBEiJ_G0028672
 protein coding gene Chr5:33703040-33746559 (-)



Homology
more
  • Human Ortholog
    SH3TC1, SH3 domain and tetratricopeptide repeats 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SH3TC1, SH3 domain and tetratricopeptide repeats 1
  • Links
    NCBI Gene ID: 54436
    neXtProt AC: NX_Q8TE82
    UniProt: Q8TE82

  • Chr Location
    4p16.1; chr4:8182072-8241803 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    809
  • Tissues
    6
  • cDNA Data
    36
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 231147 NCBI Gene Model | MGI Sequence Detail 42808 C57BL/6J ±  kb
    transcript NM_194344 RefSeq | MGI Sequence Detail 4549 C57BL/6  
    polypeptide NP_001346824 RefSeq | MGI Sequence Detail 1346 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      11 Sequences
    • InterPro Domains
      IPR001452 SH3 domain
      IPR042772 SH3 domain and tetratricopeptide repeat-containing protein SH3TC1/SH3TC2
      IPR036028 SH3-like domain superfamily
      IPR011990 Tetratricopeptide-like helical domain superfamily
      IPR019734 Tetratricopeptide repeat
    Molecular
    Reagents
    less
    • All nucleic 36
      cDNA 36

      Microarray probesets 2
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 1
      Diseases 1
      Phenotypes 30
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory