Ssh2 MGI Mouse Gene Detail - MGI:2679255 - slingshot protein phosphatase 2

Symbol

Ssh2
Name

slingshot protein phosphatase 2
Synonyms

SSH-2

Feature Type

protein coding gene
IDs

MGI:2679255
NCBI Gene: 237860
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr11:77107113-77351046 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 46.36 cM
Mapping Data

2 experiments

SNPs within 2kb

4309 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2679255	protein coding gene	Chr11:77107020-77351046 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018745	protein coding gene	Chr11:78098528-78363957 (+)
A/J	MGP_AJ_G0018711	protein coding gene	Chr11:75159827-75406152 (+)
AKR/J	MGP_AKRJ_G0018681	protein coding gene	Chr11:77445032-77691756 (+)
BALB/cJ	MGP_BALBcJ_G0018685	protein coding gene	Chr11:75545988-75788272 (+)
C3H/HeJ	MGP_C3HHeJ_G0018498	protein coding gene	Chr11:77468889-77719531 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019136	protein coding gene	Chr11:80564029-80820015 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016771	protein coding gene	Chr11:72143630-72388507 (+)
CAST/EiJ	MGP_CASTEiJ_G0018052	protein coding gene	Chr11:77869271-78109681 (+)
CBA/J	MGP_CBAJ_G0018468	protein coding gene	Chr11:84067857-84331203 (+)
DBA/2J	MGP_DBA2J_G0018577	protein coding gene	Chr11:74748767-74990386 (+)
FVB/NJ	MGP_FVBNJ_G0018567	protein coding gene	Chr11:74316149-74561956 (+)
LP/J	MGP_LPJ_G0018648	protein coding gene	Chr11:78695507-78929735 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018593	protein coding gene	Chr11:84525492-84786486 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019176	protein coding gene	Chr11:77656534-77904540 (+)
PWK/PhJ	MGP_PWKPhJ_G0017823	protein coding gene	Chr11:75500803-75746741 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017614	protein coding gene	Chr11:77254187-77518869 (+)
WSB/EiJ	MGP_WSBEiJ_G0018105	protein coding gene	Chr11:77472837-77720994 (+)

Human Ortholog

SSH2, slingshot protein phosphatase 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SSH2, slingshot protein phosphatase 2
Synonyms

SSH-2, SSH-2L
Links

HGNC:30580

NCBI Gene ID: 85464

neXtProt AC: NX_Q76I76

UniProt: Q76I76
Chr Location

17q11.2; chr17:29625938-29930276 (-) GRCh38

MGI Vertebrate Homology

Ssh2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: SSH2
Gene Tree

Ssh2

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

3
Targeted

1
Genomic Mutations

2 involving Ssh2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

61 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

32
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

742
Tissues

28
cDNA Data

95
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ssh2

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All Sequences

66
RefSeq

18
UniProt

4
CCDS

CCDS25076.1, CCDS70248.1

Ensembl

ENSMUSG00000037926 (Evidence)
NCBI Gene

237860

			Length	Strain/Species	Flank
genomic	ENSMUSG00000037926	Ensembl Gene Model \| MGI Sequence Detail	243934	C57BL/6J	± kb
transcript	ENSMUST00000181283	Ensembl \| MGI Sequence Detail	4475	Not Applicable
polypeptide	ENSMUSP00000137933	Ensembl \| MGI Sequence Detail	1429	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000015654 protein phosphatase Slingshot homolog 2

(term hierarchy)
EC

3.1.3.16, 3.1.3.48
InterPro Domains

IPR014876 DEK, C-terminal

IPR000340 Dual specificity phosphatase, catalytic domain

IPR020422 Dual specificity protein phosphatase domain

IPR043587 Protein phosphatase Slingshot-like

IPR016130 Protein-tyrosine phosphatase, active site

IPR029021 Protein-tyrosine phosphatase-like

IPR043588 Slingshot, N-terminal

IPR000387 Tyrosine-specific protein phosphatases domain

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All nucleic 97

cDNA 97

Microarray probesets 3

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MGI:2144600

Summaries

All 49

Developmental Gene Expression 3

Gene Ontology 8

Phenotypes 17
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ssh2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr103125	Chr11:77106997-77107004 (+)	-112 bp
Tssr103126	Chr11:77107006-77107105 (+)	-57 bp
Tssr103127	Chr11:77126303-77126307 (+)	19,192 bp
Tssr103131	Chr11:77230883-77230887 (+)	123,772 bp
Tssr103132	Chr11:77239085-77239095 (+)	131,977 bp
Tssr103133	Chr11:77239098-77239118 (+)	131,995 bp
Tssr103134	Chr11:77240094-77240105 (+)	132,987 bp
Tssr103135	Chr11:77347258-77347270 (+)	240,151 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24