Tg(Tcra/Tcrb)1Vbo
Transgene Detail

Summary

• Symbol: Tg(Tcra/Tcrb)1Vbo
• Name: transgene insertion 1, Harald von Boehmer
• MGI ID: MGI:2680176
• Synonyms: 6.5 TcR, HA TCR, SFE TCR, TCR-HA, TCR-SFE, TS1
• Transgene: Tg(Tcra/Tcrb)1Vbo Location: unknown
• Alliance: Tg(Tcra/Tcrb)1Vbo page

Transgene origin

• Strain of Origin: (C57BL/6J x DBA/2J)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Tcra/Tcrb)1Vbo expresses 2 genes
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tcra (MGI:98553)
  mouse	Tcrb (MGI:98578)

• Mutation details: The transgenic construct expresses a T cell receptor specific for peptide 111-119 from influenza hemagglutinin (HA), presented by class II I-E^d MHC molecules. The receptor is encoded by Tcrb-V8.2, Tcrb-J, Tcra-V4, and Tcra-J. (J:86429)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:86429 Kirberg J, et al., Thymic selection of CD8+ single positive cells with a class II major histocompatibility complex-restricted receptor. J Exp Med. 1994 Jul 1;180(1):25-34
• All: 98 reference(s)