Tg(TRAMP)8247Ng
Transgene Detail

Summary

• Symbol: Tg(TRAMP)8247Ng
• Name: transgene insertion 8247, Norman M Greenberg
• MGI ID: MGI:2384595
• Synonyms: PB-Tag, probasin/Tag, Tg(Pbsn-TAg)8247Ng, TRAMP
• Transgene: Tg(TRAMP)8247Ng Location: unknown Genetic Position: Chr16, Syntenic
• Alliance: Tg(TRAMP)8247Ng page

Histological analysis of prostate tumors in Tg(TRAMP)8247Ng/0 mice

Show the 2 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: Expression of the SV40 early region tumor antigen was driven in mouse prostate epithelium via a rat probasin promoter region fragment (-426/+28 bp). Sequencing identified greater than 20 copies of the Tg(TRAMP)8247Ng transgene (hemizygous) integrated on chromosome 16 (~18,993,000-19,272,880; mouse mm10). The region surrounding the integration site has duplicated. Currently, there are no genes annotated in this region. (J:65303, J:73560)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(TRAMP)8247Ng

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

TRAMP stands for TRansgenic Adenocarcinoma Mouse Prostate. Lines 5666 and 8079 were also produced.

Transgenic mice on a C57BL6 background develop progressive forms of prostate cancer with distant site metastasis. Forms of disease range from mild intraepithelial hyperplasia to large multinodular malignant neoplasia. Tumors are detected in the prostate as early as 10 weeks of age. The tumors have elevated levels of nuclear TRP53 and decreased androgen receptor expression.

References

• Original: J:65303 Greenberg NM, et al., Prostate cancer in a transgenic mouse. Proc Natl Acad Sci U S A. 1995 Apr 11;92(8):3439-43
• All: 337 reference(s)