In(7Oca2;7Sox6)100H Cytogenetic Marker Detail

Summary

• Symbol
  In(7Oca2;7Sox6)100H
• Name
  inversion, Chr 7, Harwell 100
• Synonyms
  In(7p;7Sox6)100H

• Feature Type
  chromosomal inversion
• IDs
  MGI:2681118

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 7, Syntenic

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  10 phenotypes from 1 allele in 1 genetic background
  1 images
  6 phenotype references
  

• All Mutations and Alleles
  1
• Radiation induced
  1
• Find Mice (IMSR)
  0 strains or lines available

This radiation induced inversion has breakpoints at the p and Sox6 loci on chromosome 7 and results in myopathy, atrioventricular heart block, and ultimately postnatal death.

References

• Summaries
  All 7

  Phenotypes 6
• Earliest
  J:61682 Hagiwara N, et al., Sox6 is a candidate gene for p100H myopathy, heart block, and sudden neonatal death. Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4180-5
• Latest
  J:123187 Cohen-Barak O, et al., Stem cell transplantation demonstrates that Sox6 represses epsilon y globin expression in definitive erythropoiesis of adult mice. Exp Hematol. 2007 Mar;35(3):358-67