Eid2 MGI Mouse Gene Detail - MGI:2681174 - EP300 interacting inhibitor of differentiation 2

Symbol

Eid2
Name

EP300 interacting inhibitor of differentiation 2
Synonyms

Cri2, EID-2

Feature Type

protein coding gene
IDs

MGI:2681174
NCBI Gene: 386655
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr7:27967306-27968593 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 16.67 cM
Mapping Data

1 experiment

SNPs within 2kb

142 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2681174	protein coding gene	Chr7:27967306-27968697 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031934	protein coding gene	Chr7:27040382-27041773 (+)
A/J	MGP_AJ_G0031913	protein coding gene	Chr7:26387131-26388522 (+)
AKR/J	MGP_AKRJ_G0031844	protein coding gene	Chr7:27061532-27062923 (+)
BALB/cJ	MGP_BALBcJ_G0031919	protein coding gene	Chr7:26547524-26548915 (+)
C3H/HeJ	MGP_C3HHeJ_G0031641	protein coding gene	Chr7:27438931-27440322 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032384	protein coding gene	Chr7:27907777-27909168 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029436	protein coding gene	Chr7:27467186-27468591 (+)
CAST/EiJ	MGP_CASTEiJ_G0030976	protein coding gene	Chr7:20736139-20737540 (+)
CBA/J	MGP_CBAJ_G0031604	protein coding gene	Chr7:29166395-29167786 (+)
DBA/2J	MGP_DBA2J_G0031757	protein coding gene	Chr7:26152467-26153858 (+)
FVB/NJ	MGP_FVBNJ_G0031714	protein coding gene	Chr7:26221655-26223046 (+)
LP/J	MGP_LPJ_G0031838	protein coding gene	Chr7:27369818-27371209 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031749	protein coding gene	Chr7:28671102-28672493 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032414	protein coding gene	Chr7:26544566-26545957 (+)
PWK/PhJ	MGP_PWKPhJ_G0030699	protein coding gene	Chr7:21152486-21153969 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030534	protein coding gene	Chr7:17556079-17557478 (+)
WSB/EiJ	MGP_WSBEiJ_G0031083	protein coding gene	Chr7:26868781-26870171 (+)

Human Ortholog

EID2, EP300 interacting inhibitor of differentiation 2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EID2, EP300 interacting inhibitor of differentiation 2
Synonyms

CRI2, EID-2
Links

HGNC:28292

NCBI Gene ID: 163126

neXtProt AC: NX_Q8N6I1

UniProt: Q8N6I1
Chr Location

19q13.2; chr19:39538707-39540161 (-) GRCh38

MGI Vertebrate Homology

Eid2 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: EID2
Gene Tree

Eid2

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

2
Endonuclease-mediated

1
Gene trapped

1
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

6 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

21
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

719
Tissues

13
cDNA Data

25
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

27
RefSeq

2
UniProt

1
CCDS

CCDS21038.1

Ensembl

ENSMUSG00000046058 (Evidence)
NCBI Gene

386655

			Length	Strain/Species	Flank
genomic	386655	NCBI Gene Model \| MGI Sequence Detail	1288	C57BL/6J	± kb
transcript	NM_198425	RefSeq \| MGI Sequence Detail	1299	FVB/N
polypeptide	Q6X7S9	UniProt \| EBI \| MGI Sequence Detail	236	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000006952 EP300-interacting inhibitor of differentiation 2

(term hierarchy)
InterPro Domains

IPR033258 EP300-interacting inhibitor of differentiation

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All nucleic 25

cDNA 25

Microarray probesets 1

Summaries

All 24

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 5
Earliest

J:86360 Ji A, et al., EID-2, a novel member of the EID family of p300-binding proteins inhibits transactivation by MyoD. Gene. 2003 Oct 30;318:35-43
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Eid2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr65454	Chr7:27967222-27967233 (+)	-78 bp
Tssr65455	Chr7:27967234-27967357 (+)	-10 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24