Cspp1 MGI Mouse Gene Detail - MGI:2681832 - centrosome and spindle pole associated protein 1

Symbol

Cspp1
Name

centrosome and spindle pole associated protein 1
Synonyms

2310020J12Rik, 4930413O22Rik

Feature Type

protein coding gene
IDs

MGI:2681832
NCBI Gene: 211660
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr1:10108212-10206993 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 2.30 cM, cytoband A2
Mapping Data

3 experiments

SNPs within 2kb

2841 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2681832	protein coding gene	Chr1:10108194-10206996 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0015833	protein coding gene	Chr1:7303937-7411434 (+)
A/J	MGP_AJ_G0015815	protein coding gene	Chr1:7359595-7461564 (+)
AKR/J	MGP_AKRJ_G0015774	protein coding gene	Chr1:7248830-7347357 (+)
BALB/cJ	MGP_BALBcJ_G0015771	protein coding gene	Chr1:7092537-7201753 (+)
C3H/HeJ	MGP_C3HHeJ_G0015605	protein coding gene	Chr1:7172674-7277543 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016225	protein coding gene	Chr1:7642365-7745448 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0013946	protein coding gene	Chr1:6202480-6307603 (+)
CAST/EiJ	MGP_CASTEiJ_G0015185	protein coding gene	Chr1:7363996-7466552 (+)
CBA/J	MGP_CBAJ_G0015578	protein coding gene	Chr1:7814835-7926390 (+)
DBA/2J	MGP_DBA2J_G0015677	protein coding gene	Chr1:6978774-7076389 (+)
FVB/NJ	MGP_FVBNJ_G0015682	protein coding gene	Chr1:6893443-6992254 (+)
LP/J	MGP_LPJ_G0015749	protein coding gene	Chr1:7516690-7619983 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015701	protein coding gene	Chr1:8470055-8586430 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016271	protein coding gene	Chr1:7152829-7273972 (+)
PWK/PhJ	MGP_PWKPhJ_G0014969	protein coding gene	Chr1:6846920-6951608 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0014749	protein coding gene	Chr1:7318893-7431155 (+)
WSB/EiJ	MGP_WSBEiJ_G0015249	protein coding gene	Chr1:7186511-7289379 (+)

Human Ortholog

CSPP1, centrosome and spindle pole associated protein 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CSPP1, centrosome and spindle pole associated protein 1
Synonyms

CSPP, CSPP-L, JBTS21
Links

HGNC:26193

NCBI Gene ID: 79848

neXtProt AC: NX_Q1MSJ5

UniProt: Q1MSJ5
Chr Location

8q13.1-q13.2; chr8:67062417-67196778 (+) GRCh38

MGI Vertebrate Homology

Cspp1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CSPP1
Gene Tree

Cspp1

Diseases

1 with human CSPP1 associations

				Human Disease	Mouse Models
				Joubert syndrome 21 IDs Joubert syndrome 21 DOID:0110990 OMIM:615636

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

39
Endonuclease-mediated

2
Gene trapped

35
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

82 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

19
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

834
Tissues

28
cDNA Data

16
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cspp1

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All Sequences

139
RefSeq

51
UniProt

8
CCDS

CCDS35511.1, CCDS87812.1

Ensembl

ENSMUSG00000056763 (Evidence)
NCBI Gene

211660

			Length	Strain/Species	Flank
genomic	ENSMUSG00000056763	Ensembl Gene Model \| MGI Sequence Detail	98782	C57BL/6J	± kb
transcript	ENSMUST00000071087	Ensembl \| MGI Sequence Detail	4355	Not Applicable
polypeptide	ENSMUSP00000068804	Ensembl \| MGI Sequence Detail	1197	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000005955 centrosome and spindle pole-associated protein 1

(term hierarchy)
InterPro Domains

IPR026708 Centrosome and spindle pole associated protein 1
GlyGen

B2RX88 1 site, 1 O-linked glycan (1 site)

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All nucleic 23

cDNA 22

Primer pair 1

Microarray probesets 20

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MGI:1915236, MGI:1919577, MGI:3035076

Summaries

All 38

Developmental Gene Expression 3

Gene Ontology 6

Phenotypes 8
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cspp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr4	Chr1:10108433-10108453 (+)	231 bp
Tssr5924	Chr1:10109987-10110017 (+)	1,790 bp
Tssr5925	Chr1:10110022-10110044 (+)	1,821 bp
Tssr5926	Chr1:10110049-10110070 (+)	1,848 bp
Tssr5927	Chr1:10127147-10127151 (+)	18,937 bp
Tssr5928	Chr1:10129485-10129491 (+)	21,276 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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