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Nlgn2 Gene Detail
Summary
  • Symbol
    Nlgn2
  • Name
    neuroligin 2
  • Synonyms
    MGC:67386, NL2, NLG2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2681835
    NCBI Gene: 216856
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:69713949-69728610 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 42.89 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    241 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2681835
 protein coding gene Chr11:69713948-69728610 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018559
 protein coding gene Chr11:70306315-70320975 (-)
A/J MGP_AJ_G0018527
 protein coding gene Chr11:67643741-67658386 (-)
AKR/J MGP_AKRJ_G0018496
 protein coding gene Chr11:69663139-69677833 (-)
BALB/cJ MGP_BALBcJ_G0018499
 protein coding gene Chr11:67971203-67986192 (-)
C3H/HeJ MGP_C3HHeJ_G0018312
 protein coding gene Chr11:69696915-69711246 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018950
 protein coding gene Chr11:72427042-72444529 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016595
 protein coding gene Chr11:64566868-64581745 (-)
CAST/EiJ MGP_CASTEiJ_G0017867
 protein coding gene Chr11:69934585-69950253 (-)
CBA/J MGP_CBAJ_G0018285
 protein coding gene Chr11:75669150-75683808 (-)
DBA/2J MGP_DBA2J_G0018394
 protein coding gene Chr11:67227373-67242050 (-)
FVB/NJ MGP_FVBNJ_G0018384
 protein coding gene Chr11:66867711-66882354 (-)
LP/J MGP_LPJ_G0018464
 protein coding gene Chr11:70868304-70884748 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018407
 protein coding gene Chr11:76275706-76290420 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018992
 protein coding gene Chr11:69926264-69940919 (-)
PWK/PhJ MGP_PWKPhJ_G0017641
 protein coding gene Chr11:67877001-67892051 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017431
 protein coding gene Chr11:69746701-69761382 (-)
WSB/EiJ MGP_WSBEiJ_G0017921
 protein coding gene Chr11:69594042-69608691 (-)



Homology
more
  • Human Ortholog
    NLGN2, neuroligin 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NLGN2, neuroligin 2
  • Links
    NCBI Gene ID: 57555
    neXtProt AC: NX_Q8NFZ4
    UniProt: Q8NFZ4

  • Chr Location
    17p13.1; chr17:7404653-7419860 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Nlgn2 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    38 phenotypes from 3 alleles in 4 genetic backgrounds
    16 phenotypes from multigenic genotypes
    57 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional ready allele are viable and fertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    106
  • GO References
    22
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    742
  • Tissues
    8
  • cDNA Data
    95
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 216856 NCBI Gene Model | MGI Sequence Detail 14662 C57BL/6J ±  kb
    transcript NM_001364137 RefSeq | MGI Sequence Detail 5567 C57BL/6  
    polypeptide Q69ZK9 UniProt | EBI | MGI Sequence Detail 836 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 96
      cDNA 95
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 120
      Developmental Gene Expression 10
      Diseases 1
      Gene Ontology 22
      Phenotypes 57
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:354849 Wutikeli H, et al., Role of Elavl-like RNA-binding protein in retinal development and signal transduction. Biochim Biophys Acta Mol Basis Dis. 2024 Sep 20;1871(1):167518
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory