Cep135 MGI Mouse Gene Detail - MGI:2681869

Symbol

Cep135
Name

centrosomal protein 135
Synonyms

Cep4, LOC381644, MGC:86039

Feature Type

protein coding gene
IDs

MGI:2681869
NCBI Gene: 381644
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr5:76736545-76794313 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 41.31 cM
Mapping Data

1 experiment

SNPs within 2kb

1770 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2681869	protein coding gene	Chr5:76736495-76794313 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029646	protein coding gene	Chr5:76782170-76842326 (+)
A/J	MGP_AJ_G0029614	protein coding gene	Chr5:73857046-73915175 (+)
AKR/J	MGP_AKRJ_G0029562	protein coding gene	Chr5:76258643-76325618 (+)
BALB/cJ	MGP_BALBcJ_G0029623	protein coding gene	Chr5:74587718-74645647 (+)
C3H/HeJ	MGP_C3HHeJ_G0029346	protein coding gene	Chr5:76634119-76694047 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030077	protein coding gene	Chr5:79846384-79910585 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027318	protein coding gene	Chr5:69483442-69543552 (+)
CAST/EiJ	MGP_CASTEiJ_G0028754	protein coding gene	Chr5:75834983-75894266 (+)
CBA/J	MGP_CBAJ_G0029315	protein coding gene	Chr5:82474081-82545124 (+)
DBA/2J	MGP_DBA2J_G0029460	protein coding gene	Chr5:73915411-73973059 (+)
FVB/NJ	MGP_FVBNJ_G0029421	protein coding gene	Chr5:73112853-73171159 (+)
LP/J	MGP_LPJ_G0029547	protein coding gene	Chr5:77217631-77281546 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029449	protein coding gene	Chr5:85640445-85703026 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030110	protein coding gene	Chr5:75812256-75871562 (+)
PWK/PhJ	MGP_PWKPhJ_G0028477	protein coding gene	Chr5:72931935-72990179 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028312	protein coding gene	Chr5:75166021-75230137 (+)
WSB/EiJ	MGP_WSBEiJ_G0028834	protein coding gene	Chr5:76132922-76193514 (+)

Human Ortholog

CEP135, centrosomal protein 135

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CEP135, centrosomal protein 135
Synonyms

CEP4, KIAA0635, MCPH8
Links

HGNC:29086

NCBI Gene ID: 9662

neXtProt AC: NX_Q66GS9

UniProt: Q66GS9
Chr Location

4q12; chr4:55948871-56033361 (+) GRCh38

MGI Vertebrate Homology

Cep135 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CEP135
Gene Tree

Cep135

Diseases

1 with human CEP135 associations

				Human Disease	Mouse Models
				primary autosomal recessive microcephaly 8 IDs primary autosomal recessive microcephaly 8 DOID:0070282 OMIM:614673

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

38 phenotypes from 3 alleles in 2 genetic backgrounds
7 phenotypes from multigenic genotypes
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Chemically induced (other)

2
Endonuclease-mediated

7
Gene trapped

2
Spontaneous

2
Targeted

3
Genomic Mutations

5 involving Cep135
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

72 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

22
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

711
Tissues

1
cDNA Data

24
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cep135

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All Sequences

45
RefSeq

13
UniProt

2
CCDS

CCDS19365.1

Ensembl

ENSMUSG00000036403 (Evidence)
NCBI Gene

381644

			Length	Strain/Species	Flank
genomic	ENSMUSG00000036403	Ensembl Gene Model \| MGI Sequence Detail	57769	C57BL/6J	± kb
transcript	ENSMUST00000121979	Ensembl \| MGI Sequence Detail	5537	Not Applicable
polypeptide	ENSMUSP00000112602	Ensembl \| MGI Sequence Detail	1140	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000005341 centrosomal protein of 135 kDa

(term hierarchy)
InterPro Domains

IPR051877 Centriole and Basal Body Structural Protein

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All nucleic 25

cDNA 25

Microarray probesets 3

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MGI:2685890

Summaries

All 43

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 16
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cep135:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr46725	Chr5:76736510-76736589 (+)	5 bp
Tssr46726	Chr5:76736634-76736650 (+)	97 bp
Tssr46727	Chr5:76736662-76736684 (+)	128 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24