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Zbtb40 Gene Detail
Summary
  • Symbol
    Zbtb40
  • Name
    zinc finger and BTB domain containing 40
  • Synonyms
    MGC:62412
  • Feature Type
    protein coding gene
  • IDs
    MGI:2682254
    NCBI Gene: 230848
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:136707043-136776112 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 69.05 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2112 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2682254
 protein coding gene Chr4:136707043-136776129 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028977
 protein coding gene Chr4:139577919-139647568 (-)
A/J MGP_AJ_G0028936
 protein coding gene Chr4:133638223-133707022 (-)
AKR/J MGP_AKRJ_G0028888
 protein coding gene Chr4:137488853-137557737 (-)
BALB/cJ MGP_BALBcJ_G0028960
 protein coding gene Chr4:134302334-134371669 (-)
C3H/HeJ MGP_C3HHeJ_G0028674
 protein coding gene Chr4:137782879-137853533 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029401
 protein coding gene Chr4:144551390-144621272 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026672
 protein coding gene Chr4:126664183-126734207 (-)
CAST/EiJ MGP_CASTEiJ_G0028106
 protein coding gene Chr4:135911795-135999287 (-)
CBA/J MGP_CBAJ_G0028639
 protein coding gene Chr4:148548717-148619190 (-)
DBA/2J MGP_DBA2J_G0028788
 protein coding gene Chr4:134041057-134109930 (-)
FVB/NJ MGP_FVBNJ_G0028755
 protein coding gene Chr4:133004526-133074038 (-)
LP/J MGP_LPJ_G0028887
 protein coding gene Chr4:139661272-139731155 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028781
 protein coding gene Chr4:152685310-152755155 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029439
 protein coding gene Chr4:137964776-138034789 (-)
PWK/PhJ MGP_PWKPhJ_G0027826
 protein coding gene Chr4:130835193-130904634 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027652
 protein coding gene Chr4:133759636-133826610 (-)
WSB/EiJ MGP_WSBEiJ_G0028184
 protein coding gene Chr4:138126087-138194870 (-)



Homology
more
  • Human Ortholog
    ZBTB40, zinc finger and BTB domain containing 40
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZBTB40, zinc finger and BTB domain containing 40
  • Synonyms
    ZNF923
  • Links
    NCBI Gene ID: 9923
    neXtProt AC: NX_Q9NUA8
    UniProt: Q9NUA8

  • Chr Location
    1p36.12; chr1:22428838-22531157 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice homozygous for a knock-out allele show a reduction in lumbar spine areal bone mineral density and decreased vertebral bone mass with reductions in trabecular bone volume, trabecular number and connectivity density.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    730
  • Tissues
    15
  • cDNA Data
    46
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000060862 Ensembl Gene Model | MGI Sequence Detail 69070 C57BL/6J ±  kb
    transcript ENSMUST00000049583 Ensembl | MGI Sequence Detail 7192 Not Applicable  
    polypeptide ENSMUSP00000061899 Ensembl | MGI Sequence Detail 1258 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • InterPro Domains
      IPR000210 BTB/POZ domain
      IPR011029 Death-like domain superfamily
      IPR011333 SKP1/BTB/POZ domain superfamily
      IPR030404 Zinc finger and BTB domain-containing protein 40, BTB/POZ domain
      IPR036236 Zinc finger C2H2 superfamily
      IPR013087 Zinc finger C2H2-type
    Molecular
    Reagents
    less
    • All nucleic 46
      cDNA 46

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2685417
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 2
      Gene Ontology 2
      Phenotypes 10
    • Earliest
      J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
    • Latest
      J:336760 Cui Y, et al., Zbtb40 Deficiency Leads to Morphological and Phenotypic Abnormalities of Spermatocytes and Spermatozoa and Causes Male Infertility. Cells. 2023 Apr 26;12(9)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory