Ddx31 MGI Mouse Gene Detail - MGI:2682639

Symbol

Ddx31
Name

DEAD/H box helicase 31
Synonyms

5830444G11Rik, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 31

Feature Type

protein coding gene
IDs

MGI:2682639
NCBI Gene: 227674
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr2:28730418-28795583 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 19.38 cM
Mapping Data

2 experiments

SNPs within 2kb

1263 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2682639	protein coding gene	Chr2:28730418-28795587 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025533	protein coding gene	Chr2:26926157-26993413 (+)
A/J	MGP_AJ_G0025510	protein coding gene	Chr2:25897046-25962845 (+)
AKR/J	MGP_AKRJ_G0025480	protein coding gene	Chr2:26753139-26820348 (+)
BALB/cJ	MGP_BALBcJ_G0025506	protein coding gene	Chr2:26018461-26084825 (+)
C3H/HeJ	MGP_C3HHeJ_G0025267	protein coding gene	Chr2:26675254-26744173 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025950	protein coding gene	Chr2:27819462-27885687 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023360	protein coding gene	Chr2:24713587-24778620 (+)
CAST/EiJ	MGP_CASTEiJ_G0024730	protein coding gene	Chr2:26584578-26651440 (+)
CBA/J	MGP_CBAJ_G0025245	protein coding gene	Chr2:28770687-28835711 (+)
DBA/2J	MGP_DBA2J_G0025378	protein coding gene	Chr2:25706408-25771670 (+)
FVB/NJ	MGP_FVBNJ_G0025340	protein coding gene	Chr2:25499901-25565578 (+)
LP/J	MGP_LPJ_G0025464	protein coding gene	Chr2:26867661-26933981 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025371	protein coding gene	Chr2:28776238-28841263 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026009	protein coding gene	Chr2:26671637-26737544 (+)
PWK/PhJ	MGP_PWKPhJ_G0024477	protein coding gene	Chr2:25519377-25583103 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024277	protein coding gene	Chr2:26804648-26869817 (+)
WSB/EiJ	MGP_WSBEiJ_G0024799	protein coding gene	Chr2:26806751-26872951 (+)

Human Ortholog

DDX31, DEAD-box helicase 31

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DDX31, DEAD-box helicase 31
Synonyms

PPP1R25
Links

HGNC:16715

NCBI Gene ID: 64794

neXtProt AC: NX_Q9H8H2

UniProt: Q9H8H2
Chr Location

9q34.13; chr9:132592997-132670401 (-) GRCh38

MGI Vertebrate Homology

Ddx31 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DDX31
Gene Tree

Ddx31

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Endonuclease-mediated

2
Gene trapped

10
Targeted

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

49 strains or lines available

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All GO Annotations

21
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

37
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ddx31

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All Sequences

43
RefSeq

7
UniProt

1
CCDS

CCDS15848.1

Ensembl

ENSMUSG00000026806 (Evidence)
NCBI Gene

227674

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026806	Ensembl Gene Model \| MGI Sequence Detail	65166	C57BL/6J	± kb
transcript	ENSMUST00000113853	Ensembl \| MGI Sequence Detail	3271	Not Applicable
polypeptide	ENSMUSP00000109484	Ensembl \| MGI Sequence Detail	687	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000032193 probable ATP-dependent RNA helicase DDX31

(term hierarchy)
EC

3.6.4.13, 5.6.2.-
InterPro Domains

IPR000629 ATP-dependent RNA helicase DEAD-box, conserved site

IPR011545 DEAD/DEAH box helicase domain

IPR025313 Domain of unknown function DUF4217

IPR001650 Helicase, C-terminal domain-like

IPR014001 Helicase superfamily 1/2, ATP-binding domain

IPR027417 P-loop containing nucleoside triphosphate hydrolase

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All nucleic 37

cDNA 37

Microarray probesets 4

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MGI:2685843

Summaries

All 36

Developmental Gene Expression 1

Gene Ontology 8

Phenotypes 8
Earliest

J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ddx31:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr16973	Chr2:28730418-28730474 (+)	28 bp
Tssr16974	Chr2:28730483-28730494 (+)	71 bp
Tssr16975	Chr2:28730616-28730665 (+)	223 bp
Tssr16976	Chr2:28730694-28730764 (+)	311 bp
Tssr16977	Chr2:28730777-28730790 (+)	366 bp
Tssr16978	Chr2:28788807-28788812 (+)	58,392 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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